218850 Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem

218850
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Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₃ClN₂OS639052-78-1

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218850-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC50 = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC50 =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.
      Catalogue Number218850
      Brand Family Calbiochem®
      SynonymsN-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
      References
      ReferencesLee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.
      Product Information
      CAS number639052-78-1
      FormLight yellow powder
      Hill FormulaC₁₆H₁₃ClN₂OS
      Chemical formulaC₁₆H₁₃ClN₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      218850

      References

      Reference overview
      Lee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-September-2020 JSW
      SynonymsN-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
      DescriptionA cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC50 = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC50 =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.
      FormLight yellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number639052-78-1
      Chemical formulaC₁₆H₁₃ClN₂OS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.