218806 Caspase Inhibitor Set III - Calbiochem

218806
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218806-1SET
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      Description
      OverviewA set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 µl (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 627610). Supplied with a data sheet.
      Catalogue Number218806
      Brand Family Calbiochem®
      References
      ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
      Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
      Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
      Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      FormLiquid
      FormulationSupplied as 2 mM in DMSO.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCaspase-1, caspase-2, caspase-3, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase Inhibitor Set III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase Inhibitor Set III - Calbiochem Certificates of Analysis

      TitleLot Number
      218806

      References

      Reference overview
      Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
      Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
      Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
      Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2008 RFH
      DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

      Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
      FormLiquid
      FormulationSupplied as 2 mM in DMSO.
      Storage -20°C
      Protect from moisture
      Do Not Freeze Ok to freeze
      Toxicity Irritant
      ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
      Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
      Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
      Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
      Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
      Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
      Nicholson, D.W., et al. 1995. Nature 376, 37.
      Thornberry, N.A., et al. 1992. Nature 356, 768.