219381 Cathepsin K Inhibitor III - Calbiochem

219381
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₄₃N₇O₆

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219381-1MG
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      Glass bottle 1 mg
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      Description
      OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.
      Catalogue Number219381
      Brand Family Calbiochem®
      Synonyms1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂, Inhibitor I
      References
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
      Product Information
      ATP CompetitiveN
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₀H₄₃N₇O₆
      Chemical formulaC₃₀H₄₃N₇O₆
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCathepsin K
      Primary Target K<sub>i</sub>9.7 nM against cathepsin K
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin K Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin K Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      219381

      References

      Reference overview
      Wang, D., et al. 2002. Biochemistry 41, 8849.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2008 RFH
      Synonyms1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂, Inhibitor I
      DescriptionA cell-permeable, potent, selective, reversible inhibitor of cathepsin K (Ki,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (Ki,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₄₃N₇O₆
      Peptide SequenceH-Phe-Leu-NHNH-CO-NHNH-Leu-Z
      Purity≥97% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.