219343 Cathepsin S, Human, Recombinant, E. coli

219343
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219343-25UG
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      Plastic ampoule 25 μg
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      Description
      OverviewRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase preferentially expressed in macrophages and microglia. Exhibits high specific activity.
      Note: 1 mU = 1 milliunit.
      Catalogue Number219343
      Brand Family Calbiochem®
      References
      ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
      EC number3.4.22.27
      FormLiquid
      FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥30,000 mU/mg protein
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Harmful
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cathepsin S, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      Cathepsin S, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      219343

      References

      Reference overview
      Liuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.

      Citations

      Title
    • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-September-2007 RFH
      DescriptionRecombinant, human cathepsin S expressed in E. coli without a tag or fusion protein. A major lysosomal cysteine proteinase that is preferentially expressed in macrophages and microglia. Shown to be involved in the processing of antigenic peptides for presentation by MHC Class II molecules on the surface of antigen-presenting cells by mediating invariant (Ii) chain degradation. Inhibition of cathepsin S results in impaired antigen-presentation.
      FormLiquid
      FormulationIn 35 mM potassium phosphate, 35 mM Sodium acetate, 2 mM DTT, 2 mM EDTA, 50% ethylene glycol, pH 6.5.
      EC number3.4.22.27
      Purity≥90% by SDS-PAGE
      Specific activity≥30,000 mU/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-VVR-AMC per min at 37°C, pH 6.5. Note: 1 mU = 1 milliunit.
      Storage ≤ -70°C
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Harmful
      ReferencesLiuzzo, J.P., et al. 1999. Mol. Med. 5, 334.
      Riese, R.J., et al. 1998. J. Clin. Invest. 101, 2351.
      Sukhova, G.K., et al. 1998. J. Clin. Invest. 102, 576.
      Kirschke, H., and Wiederanders, B. 1994. Methods Enzymol. 244, 500.
      Xin, X.Q., et al. 1992. Arch. Biochem. Biophys. 299, 334.
      Kirschke, H., et al. 1989. Biochem. J. 264, 467.
      Citation
    • Ayman Marei, et al. (2005) Superior T cell activation by ESAT-6 as compared with the ESAT-6-CFP-10 complex. International Immunology 17, 1439-1446.