217713 Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem

217713
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₂₂N₆O₃S444722-95-6

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217713-1MG
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      217713-5MG
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          Description
          OverviewA cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
          Catalogue Number217713
          Brand Family Calbiochem®
          Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
          References
          ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
          Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
          Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
          Product Information
          CAS number444722-95-6
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₁₈H₂₂N₆O₃S
          Chemical formulaC₁₈H₂₂N₆O₃S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCdk1/cyclin B, Cdk2/cyclin A3
          Primary Target IC<sub>50</sub>9.5 nM, 5.4 nM against Cdk1/cyclin B, Cdk2/cyclin A3, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Cdk1/2 Inhibitor II, NU6102 - CAS 444722-95-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          217713

          References

          Reference overview
          Hardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
          Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
          Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms6-Cyclohexylmethoxy-2-(4ʹ-sulfamoylanilino)purine
          DescriptionA cell-permeable purine analog that displays anti-proliferative properties and acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM, respectively). Displays greater selectivity for Cdk's over other kinases tested (IC50 = 30 nM, 600 nM, 800 nM, 900 nM, and 1.6 µM for Cdk2/A, ROCKII, PDK1, DYRK1A, and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth (GI50 of 8 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number444722-95-6
          Chemical formulaC₁₈H₂₂N₆O₃S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (20 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesHardcastle, I.R., et al. 2004. J. Med. Chem. 47, 3710.
          Sayle, K.L., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3079.
          Davies, T.G., et al. 2002. Nat. Struct. Biol. 9, 745.