217714 Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem

217714
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Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₃F₂N₇O₂S₂443798-55-8

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217714-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
      Catalogue Number217714
      Brand Family Calbiochem®
      Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
      References
      ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.
      Product Information
      CAS number443798-55-8
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₃F₂N₇O₂S₂
      Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk2/cyclin A
      Primary Target IC<sub>50</sub>20 nM, 35 nM and 92 nM for anti-proliferative properties in HCT-116, HeLa, and A375 cells, respectively; 600 pM and 500 pM, against Cdk1/cyclin B and Cdk2/cyclin A, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      217714

      References

      Reference overview
      Lin, R., et al. 2005.J. Med. Chem. 48, 4208.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-December-2009 RFH
      Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
      DescriptionA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number443798-55-8
      Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml), Acetone or THF
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.