219365 Coagulation Factor V, Human Plasma

219365
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219365-100UG
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      Plastic ampoule 100 μg
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      Description
      OverviewNative coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca2+, and membrane phospholipids are cofactors that form a "prothrombinase" complex with Factor X, enabling its proteolytic activation of prothrombin to thrombin.
      Catalogue Number219365
      Brand Family Calbiochem®
      SynonymsProaccelerin, Labile Factor, Ac-globulin, Ac-g
      References
      ReferencesWalker, F.J. 1992. J. Biol. Chem. 267, 19896.
      Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
      Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
      Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
      Krieg, U.C., et al. 1987. Biochemistry 26, 103.
      Product Information
      CAS number9001-24-5
      FormLiquid
      FormulationIn 50% glycerol/H₂O (v/v).
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥20 units/mg protein (clotting assay). Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Coagulation Factor V, Human Plasma SDS

      Title

      Safety Data Sheet (SDS) 

      Coagulation Factor V, Human Plasma Certificates of Analysis

      TitleLot Number
      219365

      References

      Reference overview
      Walker, F.J. 1992. J. Biol. Chem. 267, 19896.
      Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
      Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
      Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
      Krieg, U.C., et al. 1987. Biochemistry 26, 103.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      SynonymsProaccelerin, Labile Factor, Ac-globulin, Ac-g
      DescriptionNative coagulation factor V from human plasma. Thrombin cleaves Factor V to yield activated Factor Va, which exhibits 50-fold greater activity than the precursor molecule. Factor Va, Ca2+, and membrane phospholipids are cofactors which form a "prothrombinase" complex with Factor Xa, enabling its proteolytic activation of prothrombin to thrombin.
      FormLiquid
      FormulationIn 50% glycerol/H₂O (v/v).
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number9001-24-5
      Purity≥95% by SDS-PAGE
      Specific activity≥20 units/mg protein (clotting assay). Clotting activity is determined by comparison to a standard curve produced using normal pooled human plasma
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Do not store below -20°C.
      Toxicity Standard Handling
      Merck USA index14, 3919
      ReferencesWalker, F.J. 1992. J. Biol. Chem. 267, 19896.
      Monkovic, D.D., and Tracy, P.B. 1990. J. Biol. Chem. 265, 17132.
      Krishnaswamy, S., et al. 1989. J. Biol. Chem. 264, 3160.
      Lee, C.D., and Mann, K.G. 1989. Blood 73, 185.
      Krieg, U.C., et al. 1987. Biochemistry 26, 103.