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Merck

Titrisol® Concentrates

Introduction

For decades, Titrisol® concentrates have been commonly used in analytical laboratories for the preparation of volumetric solutions and calibration standards. These concentrates provide flexibility in solution preparation by dilution to achieve individual concentrations, as required by the analytical method or application.

In a significant step towards enhanced sustainability and user convenience, Titrisol® concentrates have shifted from conventional polyethylene (PE) ampoule packaging to small HDPE (high-density polyethylene) bottles. This packaging change leads to a measurable reduction in non-recyclable and multi-component materials. It also minimizes the use of materials such as polyethylene (PE) funnels, polyvinyl chloride (PVC) blister packs, and outer cartons. The new HDPE bottle packaging reduces environmental impact and enhances handling efficiency in laboratory workflows.

More Sustainable Packaging

On the left side, there is a hydrochloric acid ampoule packaging consisting of a small, white polyethylene (PE) ampoule lying in front of a rectangular cardboard carton with a printed label. Beside the ampoule are a transparent PE funnel and a clear PVC blister pack used to hold the contents securely. The label on the ampoule and carton includes chemical information, hazard symbols, and the brand’s logo in green and yellow. On the right side of the image is a high-density polyethylene (HDPE) bottle with a white body and a black screw cap. The bottle is labeled with product details for hydrochloric acid, specifying a concentration of 0.1 mol/l (0.1 N). The label includes text in both English and German, a QR code, hazard symbols, and branding with a green and yellow color scheme.

Figure 1.(a) Ampoule packaging (PE ampoule, PE funnel, carton, PVC blister pack),
(b) HDPE bottle packaging

The transition from ampoule-based packaging to small HDPE bottles results in the elimination of several packaging components, including cartons, polyethylene (PE) funnels, and polyvinyl chloride (PVC) blister packs. PVC is classified as a material of environmental concern due to its limited recyclability and associated disposal challenges. This change is projected to reduce packaging waste by approximately 2.6 metric tons annually, corresponding to an estimated reduction of 7.5 metric tons of CO₂ equivalent emissions.

A bar graph comparing the individual packaging weights of two types of containers: ampoules and HDPE bottles. The vertical axis represents the packaging weight in grams, ranging from 0 to 80 grams. There are four bars in total. The first two bars compare a 60 ml ampoule, weighing 43 grams, and a 100 ml HDPE bottle, weighing 21.3 grams. The next two bars show a 170 ml ampoule weighing 67.4 grams and a 250 ml HDPE bottle weighing 39.3 grams. The ampoule packaging bars are colored purple, while the HDPE bottle packaging bars are colored green. Each bar displays its corresponding weight value in bold white text. Below the graph, there is a legend that visually associates the purple bar with ampoule packaging by showing a photo of the ampoule packaging on the left, and the green bar with HDPE bottle packaging by showing a photo of the HDPE bottle on the right. Each packaging type is labeled with its respective name and icon.

Figure 2.Titrisol® concentrates packaging weight reduction.

Titrisol® Product Line

Titrisol® concentrates are available to prepare volumetric solutions for titration and calibration standards for trace analysis.

Titrisol® Volumetric Solution Concentrates

These concentrates are used in titration to prepare a volumetric solution for determining the quantitative amount of a specific analyte.

Titrisol® volumetric solution concentrates in HDPE bottles:

  • Sodium hydroxide (0.1 mol/L), 100 mL
  • Sodium hydroxide (1 mol/L), 250 mL
  • Hydrochloric acid (0.1 mol/L), 100 mL
  • Hydrochloric acid (1 mol/L), 250 mL
  • Sodium thiosulfate (0.1 mol/L), 100 mL
  • Sulfuric acid (0.05 mol/L), 100 mL

Titrsiol® AAS Standard Concentrates

These concentrates are used to prepare calibration standards required for atomic absorption spectroscopic analysis.

Titrisol® AAS calibration standard concentrates in HDPE bottles:

  • Iron standard, 1000 mg Fe (FeCl3 in 15% HCl), 100 mL
  • Copper Standard, 1000 mg Cu (CuCl2 in H2O), 100 mL

Titrisol® Buffer Calibration Solution Concentrates

These concentrates are used to prepare a buffer solution to calibrate pH instruments.

Titrisol® buffer calibration solution concentrates in HDPE bottles:

  • Buffer calibration solution pH 7.00, 100 mL
  • Buffer calibration solution pH 4.00, 100 mL
  • Buffer calibration solution pH 3.00, 100 mL
  • Buffer calibration solution pH 9.00, 100 mL

Features and benefits of the Titrisol® HDPE bottles

  • Contributes to more sustainability: By reducing the use of PE, PVC, and carton packaging materials.
  • Convenient and easy to use: The new bottles are designed for easy and hassle-free handling during solution preparation. The required volume can be directly dispensed into the volumetric flask using a funnel, streamlining the process and saving time
  • Flexibility in concentration: The concentrates in bottles allow for flexible dilution, enabling users to prepare solutions at concentrations tailored to specific analytical requirements, thereby supporting method adaptability
  • Cost Saving: The packaging reduces the volume and type of packaging materials used, which contributes to lower waste disposal and transportation costs, supporting cost-efficient laboratory operations

Preparation of Solutions Using Titrisol® Concentrates

Six-step illustrated process showing solution preparation using a volumetric flask, funnel, reagent bottle, and water bottle with inversion steps for mixing.

Figure 3.Preparation of solutions using Titrisol® concentrates (See steps below).

  • Step 1: Use a measuring flask, a glass funnel, and a wash bottle filled with distilled water.
  • Step 2: Open the Titrisol® HDPE bottle and use a glass funnel to transfer its content into the measuring flask.
  • Step 3: Fill the empty Titrisol® bottle with distilled water, close the lid, and turn it over 180° to mix. Reopen the bottle and transfer the rinse into the volumetric flask. Repeat this rinsing step 2-3 times to ensure complete transfer.
  • Step 4: Rinse the glass funnel by pouring distilled water along its walls into the measuring flask.
  • Step 5: Remove the glass funnel and fill the measuring flask with distilled water up to the mark at 20 °C.
  • Step 6: Cap the volumetric flask and invert it a few times (180°) to homogenize the solution.

Note: We recommend performing a titer determination before proceeding with sample analysis

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