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Merck

251700

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride

UPA inhibitor, solid

Synonym(s):

1,5-DNS-GGACK, 2HCl

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone, Dihydrochloride, Effective irreversible inhibitor of uPA, Factor Xa, and urokinase.

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

soluble (Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.)

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Primary Target
UPA
Product does not compete with ATP.
Reversible: no
Target IC50: 100 nM for factor Xa

Disclaimer

Toxicity: Standard Handling (A)

General description

Effective irreversible inhibitor of uPA, Factor Xa, and urokinase. Fluorophore allows direct monitoring of interactions of labeled enzyme. Does not inhibit tPA.

Other Notes

Bajaj, S.P., et al. 1992. Proc. Natl. Acad. Sci. USA89, 152.
Bergmeyer, H.V. 1984. Methods Enzym. Anal. 5, 375.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.

Preparation Note

Following initial thaw, aliquot and refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Reconstitute at 1 mg/ml in 10 mM HCl. Dilute with physiological buffers just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Margaux R Audett et al.
Molecular biology of the cell, 33(1), ar1-ar1 (2021-10-28)
KNL1 is a large intrinsically disordered kinetochore (KT) protein that recruits spindle assembly checkpoint (SAC) components to mediate SAC signaling. The N-terminal region (NTR) of KNL1 possesses two activities that have been implicated in SAC silencing: microtubule (MT) binding and

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