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Merck

539749

PTP1B Inhibitor

InSolution, ≥97%

Synonym(s):

PTP Inhibitor XXII, InSolution PTP1B Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C26H19Br2N3O7S3
Molecular Weight:
741.45
NACRES:
NA.77
UNSPSC Code:
12352200

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Product Name

PTP1B Inhibitor, InSolution, ≥97%

assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively
Reversible: yes

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.

Other Notes

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

Packaging

Packaged under inert gas

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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