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MAB10139 Anti-LIM Domain Only 2 Antibody, clone 2E6

Detect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB.

Anti-LIM Domain Only 2 Antibody, clone 2E6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: LMO2, RHOM2, TTG2, RBTN2, Rhombotin-2, RBTNL1 UniProt Number: P25791
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MAB10139
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMCulture SupernatantMonoclonal Antibody
Description
Catalogue NumberMAB10139
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-LIM Domain Only 2 Antibody, clone 2E6
Background InformationLIM Domain only 2 (LMO2) encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
References
Product Information
FormatCulture Supernatant
PresentationLiquid containing 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenRecombinant human LMO2
Clone2E6
HostMouse
SpecificityHuman
IsotypeIgG2a
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryLMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
Gene Symbol
  • LMO2
  • RHOM2
  • TTG2
  • RBTN2
  • Rhombotin-2
  • RBTNL1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P25791 # Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
SIZE: 158 amino acids; 18358 Da
SUBUNIT: Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and JARID1A.
SUBCELLULAR LOCATION: Nucleus (Potential).
DOMAIN: SwissProt: P25791 The second LIM zinc-binding domain interacts with JARID1A.
DISEASE:SwissProt: P25791 # A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
SIMILARITY: Contains 2 LIM zinc-binding domains.
Molecular Weight18kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at 4°C from date of shipment
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB10139 04053252466410

Documentation

Anti-LIM Domain Only 2 Antibody, clone 2E6 SDS

Title

Safety Data Sheet (SDS) 

References

Reference overviewPub Med ID
The significance of LMO2 expression in the progression of prostate cancer
Ma, S, et al
J Pathol, 211:278-85 (2007)  2007

17167821 17167821
The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas
Natkunam, Yasodha, et al
Blood, 109:1636-42 (2007)  2007

17038524 17038524

Data Sheet

Title
MOUSE ANTI-LIM DOMAIN ONLY 2 MONOCLONAL ANTIBODY