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MABC567 Anti-Somatoliberin/GHRH Antibody, clone 1B4.2

This Anti-Somatoliberin Antibody, clone 1B4.2 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GHRH .

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: GHRH, GHRF UniProt Number: P01286
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MABC567
100 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC567
DescriptionAnti-Somatoliberin/GHRH Antibody, clone 1B4.2
Alternate Names
  • Somatoliberin
  • Growth hormone-releasing factor
  • GRF
  • Growth hormone-releasing hormone
  • GHRH
  • Somatocrinin
  • Somatorelin
  • Sermorelin
  • Somatoliberin/GHRH
Background InformationThe human GHRH (also known as GHRF) gene (Gene ID 2691) encodes the 108 aa Somatoliberin preproprotein (UniProt P01286; also known as GHRH, GRF, Growth hormone-releasing factor, Growth hormone-releasing hormone, INN: Sermorelin, Sermorelin, Somatocrinin, Somatorelin). Post-translatioinal removal of the signal peptide (aa 1-20) and the two propeptide sequences (aa 21-31 and aa 76-108) releases the 44 aa mature Somatoliberin (aa 32-75) that functions as a ligand to stimulate growth hormone (GH) release from the pituitary. Variant GHRH receptors are found in several types of tumors. Antagonists against such receptors are reported to inhibit tumors growth. Defects in GHRH gene cause dwarfism and hypersecretion of somatoliberin is linked to gigantism.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Somatoliberin Antibody, clone 1B4.2 is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GHRH .
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Somatoliberin/GHRH in human cerebral cortex tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to mature human somatoliberin sequence.
EpitopeMature somatoliberin
Clone1B4.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 1B4.2 is expected to detect prepro-, pro-, and mature somatoliberin.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • GHRH
  • GHRF
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~12 kDa observed. Preprosomatoliberin (12.4 kDa calculated); Prosomatoliberin (10.9 kDa calculated); Mature somatoliberin (10.4 kDa calculated). Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human lung tissue lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected Somatoliberin/GHRH in 10 µg of human lung tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC567 04055977175325

Documentation

Anti-Somatoliberin/GHRH Antibody, clone 1B4.2 SDS

Title

Safety Data Sheet (SDS) 

Anti-Somatoliberin/GHRH Antibody, clone 1B4.2 Certificates of Analysis

TitleLot Number
Anti-Somatoliberin/GHRH, clone 1B4.2 - 3327581 3327581
Anti-Somatoliberin/GHRH, clone 1B4.2 - 3792019 3792019
Anti-Somatoliberin/GHRH, clone 1B4.2 - 4136260 4136260
Anti-Somatoliberin/GHRH, clone 1B4.2 -Q2578153 Q2578153

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.