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AB6021 Anti-Stabilin-1 Antibody, CT

Anti-Stabilin-1 Antibody, C-terminus is an antibody against Stabilin-1 for use in WB, IH(P) & IF.

Anti-Stabilin-1 Antibody, CT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: CLEVER-1, FEEL-1, FEEL1, FELE-1, FEX1 , KIAA0246, STAB-1 UniProt Number: Q9NY15
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AB6021
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P), IFRbUnpurifiedPolyclonal Antibody
Description
Catalogue NumberAB6021
DescriptionAnti-Stabilin-1 Antibody, CT
Alternate Names
  • Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1
  • MS-1 antigen
  • common lymphatic endothelial and vascular endothelial receptor-1
  • fasciclin egf-like, laminin-type egf-like, and link domain-containing scavenger receptor-1
  • stabilin 1
Background InformationStabilin-1 and Stabilin-2 constitute a novel family of fasciclin domain-containing hyaluronan receptor homologs that may play a role in cell-cell and cell-extracellular matrix interactions in vascular function and inflammatory processes. Stabilin-1 is a transmembrane protein, expressed in endothelial cells within the sinusoidal regions of liver, spleen, and lymph tissues as well as macrophages. Stabilin-2 is absent from the latter (Politz, 2002).
References
Product Information
FormatUnpurified
Control
  • HUVEC lysate.
PresentationUnpurified rabbit polyclonal in serum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Stabilin-1 Antibody, C-terminus is an antibody against Stabilin-1 for use in WB, IH(P) & IF.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
  • Immunofluorescence
Application NotesImmunohistochemistry Analysis: 1:500 dilution from a previous lot detected Stabilin-1 in human placental tertiary villi.
Immunofluorescence Analysis: A previous lot of Anti-Stabilin-1, C-terminus was shown to positively stain using immunofluorescence techniques (Kzhyshkowska, 2008).
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human Stabilin-1.
EpitopeC-terminus
HostRabbit
SpecificityThe antibody recognizes the C-terminus of Stabilin-1 within the cytoplasmic region of a cell.
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with human. Other notable species homologies include mouse (87%) and rat (83%).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • CLEVER-1
  • FEEL-1
  • FEEL1
  • FELE-1
  • FEX1
  • KIAA0246
  • STAB-1
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
SUBUNIT STRUCTURE: Interacts with CHID1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.
TISSUE SPECIFICITY: High levels found in spleen, lymph node, liver and placenta. Also expressed in endothelial cells.
SEQUENCE SIMILARITIES: Contains 16 EGF-like domains.
Contains 7 FAS1 domains.
Contains 2 laminin EGF-like domains.
Contains 1 Link domain.
Molecular Weight~ 275 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western blot in HUVEC lysate.
Western blot Analysis: 1:1,000 dilution of this antibody detected Stabilin-1 on 10 µg of HUVEC lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt if stored in undiluted aliquots.
Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB6021 04053252404603

Documentation

Anti-Stabilin-1 Antibody, CT SDS

Title

Safety Data Sheet (SDS) 

Anti-Stabilin-1 Antibody, CT Certificates of Analysis

TitleLot Number
Anti-Stabilin-1, C-terminus - 3647964 3647964
Anti-Stabilin-1, C-terminus - 3872393 3872393
Anti-Stabilin-1, C-terminus -2688589 2688589
Anti-Stabilin-1, C-terminus -2853777 2853777
Anti-Stabilin-1, C-terminus Polyclonal Antibody 2882929
Anti-Stabilin-1, C-terminus Polyclonal Antibody 2896202
Anti-Stabilin-1, C-terminus Polyclonal Antibody 3052522

References

Reference overviewPub Med ID
HOXC9 regulates formation of parachordal lymphangioplasts and the thoracic duct in zebrafish via stabilin 2.
Stoll, SJ; Bartsch, S; Kroll, J
PloS one  8  e58311  2013

Show Abstract 		23484014 23484014