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AB6019 Anti-Thymosin beta-4 Antibody

Anti-Thymosin beta-4 Antibody is an antibody against Thymosin beta-4 for use in WB & IC.

Anti-Thymosin beta-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: FX, TB4X, TMSB4, THYB4, PTMB4, TMSB4X, Fx UniProt Number: P62328
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AB6019
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB6019
DescriptionAnti-Thymosin beta-4 Antibody
Alternate Names
  • thymosin beta 4, X-linked
  • prothymosin beta-4
  • thymosin, beta 4
  • thymosin, beta 4, X chromosome
  • T beta-4
Background InformationThymosin beta-4 is the most prevalent of the cytoplasmic G-actin binding proteins belonging to the highly conserved thymosin beta family. Known to bind actin monomers, Thymosin beta-4 sequesters G-actin in a manner that prevents actin polymerization. Thymosin beta-4 plays several important roles including induction of tissue remodeling, wound healing in both cell and tissue injuries, and cell differentiation via mechanisms that have yet to be fully elucidated. It is involved in the regulation of the cytoskeleton, and thereby influences an array of cellular processes. Within the brain, Thymosin beta-4 is associated with the neurite extension and migration of neurons. Expression has been observed in various hemopoietic and lymphoid malignant cell lines.
References
Product Information
FormatAffinity Purified
Control
  • Recombinant Thymosin beta-4
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Thymosin beta-4 Antibody is an antibody against Thymosin beta-4 for use in WB & IC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Application NotesWestern Blot (Snap i.d.®) Analysis: 1 µg/mL from a previous lot detected Thymosin beta-4 on 10 µg of recombinant Thymosin beta-4.

Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Thymosin beta-4 in NIH/3T3, HeLa, and A431 cells.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the internal domain of human Thymosin beta-4.
EpitopeUnknown
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityTh antibody recognizes the internal domain of Thymosin beta-4.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteDemonstrated to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • FX
  • TB4X
  • TMSB4
  • THYB4
  • PTMB4
  • TMSB4X
  • Fx
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Plays an important role in the organization of the cytoskeleton (by similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.

Seraspenide inhibits the entry of hematopoeitic pluripotent stem cells into the S-phase (by similarity).

SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton.

TISSUE SPECIFICTY: Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.

INDUCTION: By alpha interferons. Decreased levels in THP-1 cells after treatment with recombinant interferon-lambda.

SEQUENCE SIMILARITIES: Belongs to the thymosin beta family.
Molecular Weight~ 33kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in recombinant Thymosin beta-4.

Western Blot Analysis: 1 µg/mL of the antibody detected Thymosin beta-4 on 10 µg of recombinant Thymosin beta-4.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB6019 04053252551932

Documentation

Anti-Thymosin beta-4 Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Thymosin beta-4 Antibody Certificates of Analysis

TitleLot Number
Anti-Thymosin beta-4 - 2120078 2120078
Anti-Thymosin beta-4 - 2161201 2161201
Anti-Thymosin beta-4 - 2420503 2420503
Anti-Thymosin beta-4 - 2438698 2438698
Anti-Thymosin beta-4 - 1956739 1956739
Anti-Thymosin beta-4 - 2318056 2318056
Anti-Thymosin beta-4 - 3387634 3387634
Anti-Thymosin beta-4 - 3842844 3842844
Anti-Thymosin beta-4 - 4040814 4040814
Anti-Thymosin beta-4 - NG1905714 NG1905714
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