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233105 CL-82198 - CAS 1188890-36-9 - Calbiochem

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM).

CL-82198 - CAS 1188890-36-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMP-13
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233105
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1188890-36-9C₁₇H₂₂N₂O₃ · HCl

Products

Catalogue NumberPackaging Qty/Pack
233105-5MGCN Plastic ampoule 5 mg
Description
OverviewA selective inhibitor of MMP-13 (IC50 = 10 µM). Binds to the S1′ pocket of MMP-13 with its morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
Catalogue Number233105
Brand Family Calbiochem®
References
ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
Product Information
CAS number1188890-36-9
ATP CompetitiveN
FormLight yellow solid
Hill FormulaC₁₇H₂₂N₂O₃ · HCl
Chemical formulaC₁₇H₂₂N₂O₃ · HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-13
Primary Target IC<sub>50</sub>10 µM against MMP-13
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
233105-5MGCN 04055977217629

Documentation

CL-82198 - CAS 1188890-36-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CL-82198 - CAS 1188890-36-9 - Calbiochem Certificates of Analysis

TitleLot Number
233105

References

Reference overview
Chen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-April-2011 RFH
DescriptionA selective inhibitor of MMP-13 (IC50 = 10 µM) that does not appear to act by chelating Zn2+. Binds within the entire S1' pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.
FormLight yellow solid
CAS number1188890-36-9
Chemical formulaC₁₇H₂₂N₂O₃ · HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityH₂O (25 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChen, J.M., et al. 2000. J. Am. Chem. Soc. 122, 9648.