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250233 Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem

Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2, is a cell-permeable fungal toxin that inhibits cytoplasmic division by blocking the formation of contractile microfilaments.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Blocking the formation of contractile microfilaments
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250233
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
14930-96-2C₂₉H₃₇NO₅

Products

Catalogue NumberPackaging Qty/Pack
250233-5MGCN Alu drum 5 mg
Description
OverviewCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Catalogue Number250233
Brand Family Calbiochem®
References
ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
Product Information
CAS number14930-96-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₃₇NO₅
Chemical formulaC₂₉H₃₇NO₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2, is a cell-permeable fungal toxin that inhibits cytoplasmic division by blocking the formation of contractile microfilaments.
Biological Information
Primary TargetBlocking the formation of contractile microfilaments
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRO0205000
Safety Information
R PhraseR: 26/27/28-63

Very toxic by inhalation, in contact with skin and if swallowed.
Possible risk of harm to the unborn child.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
250233-5MGCN 04055977199147

Documentation

Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem Certificates of Analysis

TitleLot Number
250233

References

Reference overview
Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2009 JSW
DescriptionCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
FormWhite solid
CAS number14930-96-2
RTECSRO0205000
Chemical formulaC₂₉H₃₇NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml) or Methanol (20 mg/ml). Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Merck USA index14, 2790
ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.