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444898 Mastoparan - CAS 72093-21-1 - Calbiochem

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii.

Mastoparan - CAS 72093-21-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: INLKALAALAKKIL

Primary Target: Na+,K+-ATPase activity
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
72093-21-1C₇₀H₁₃₁N₁₉O₁₅

Products

Catalogue NumberPackaging Qty/Pack
444898-1MGCN Plastic ampoule 1 mg
Description
OverviewA cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca2+. Acts as a calmodulin antagonist and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum. Also reported to inhibit Na+,K+-ATPase activity (IC50 = 7.5 µM).
Catalogue Number444898
Brand Family Calbiochem®
SynonymsINLKALAALAKKIL
References
ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res. 771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science 259, 77.
Komatsu, M., et al. 1992. Endocrinology 130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.
Product Information
CAS number72093-21-1
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₀H₁₃₁N₁₉O₁₅
Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetNa+,K+-ATPase activity
Primary Target IC<sub>50</sub>7.5 µM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide ContentY
Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444898-1MGCN 04055977186192

Documentation

Mastoparan - CAS 72093-21-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mastoparan - CAS 72093-21-1 - Calbiochem Certificates of Analysis

TitleLot Number
444898

References

Reference overview
Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res. 771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science 259, 77.
Komatsu, M., et al. 1992. Endocrinology 130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-October-2015 JSW
SynonymsINLKALAALAKKIL
DescriptionA cell-permeable synthetic peptide with a sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on Gi and Go rather than Gs. Potent factor in mitochondrial permeability transition pore. Inhibits calmodulin and activates phospholipase A2. Causes a transient Ca2+ release from the sarcoplasmic reticulum.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
CAS number72093-21-1
Chemical formulaC₇₀H₁₃₁N₁₉O₁₅
Peptide SequenceH-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂
Purity≥97% by HPLC
SolubilityH₂O (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res. 771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science 259, 77.
Komatsu, M., et al. 1992. Endocrinology 130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun. 179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.