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FCABS400F Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC

Milli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Inflammation & Autoimmune Mechanisms Gene Symbol: FCER1G, OTTHUMP00000063478 UniProt Number: P30273
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FCABS400F
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, H, MFCRbFITCPolyclonal Antibody
Description
Catalogue NumberFCABS400F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark® Anti-FcεRI Antibody, γ subunit-FITC
Alternate Names
  • Fc fragment of IgE high affinity I receptor for gamma polypeptide
  • Fc-epsilon RI-gamma
  • FceRI gamma
  • IgE Fc receptor subunit gamma
  • Immunoglobulin E receptor, high affinity,gamma chain
Background InformationType I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.
References
Product Information
FormatFITC
Control
  • RBL cells
PresentationPurified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenSynthetic peptide corresponding to amino acids 80-86 of γ-subunit of Fc receptors.
HostRabbit
SpecificityRecognizes and is specific for FcεRI, γ-subunit.
IsotypeIgG
Species Reactivity
  • Rat
  • Human
  • Mouse
Species Reactivity NoteShown to demonstrated to work on Rat. Unconjugated antibody (Cat No. 06-727) has been shown to work on Human and Mouse.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.
Gene Symbol
  • FCER1G
  • OTTHUMP00000063478
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P30273 # The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.

SIZE: 86 amino acids; 9667 Da

SUBUNIT: IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors.

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

SIMILARITY: SwissProt: P30273 ## Belongs to the CD3Z/FCER1G family. & Contains 1 ITAM domain.
Molecular Weight10 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using RBL cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
FCABS400F 04053252757730

Documentation

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC SDS

Title

Safety Data Sheet (SDS) 

Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC Certificates of Analysis

TitleLot Number
Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2110508 2110508
Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2148272 2148272
Milli-Mark Anti-Fc#949;RI, #947; subunit-FITC - 2167760 2167760
Milli-Mark Anti-FcRI, subunit-FITC - 2199681 2199681
Milli-Mark Anti-FcRI, subunit-FITC - 2219398 2219398
Milli-Mark#174; Anti-FcRI, subunit-FITC - 2022624 2022624
Milli-Mark#174; Anti-FcRI, subunit-FITC - 2032725 2032725
Milli-Mark#174; Anti-FcRI, subunit-FITC - 2066316 2066316
Milli-Mark#174; Anti-FcRI, subunit-FITC - 2106930 2106930
Milli-Mark#174; Anti-FcRI, subunit-FITC - Q1964938 Q1964938
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