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855010 NovaSyn®TGT alcohol resin

Novabiochem®

NovaSyn®TGT alcohol resin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 478242-36-3
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855010
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Overview

Replacement Information

Key Spec Table

CAS #
478242-36-3

Products

Catalogue NumberPackaging Qty/Pack
8.55010.0001 Glass bottle 1 g
8.55010.0005 Plastic bottle 5 g
8.55010.0025 Plastic bottle 25 g
Description
Catalogue Number855010
Replaces01-64-0066
Brand Family Novabiochem®
Background InformationNovaSyn® TGT alcohol resin is derived from TG amino resin by acylation with Bayer's 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2, 3] or SOCl2 [4, 5] in toluene. The unstable trityl chloride resin should then be used immediately.

Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His.

Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin.

This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].

Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

The product number for this product was previously 01-64-0066.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number478242-36-3
HS Code3903 90 90
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Storage class10 - 13 Other liquids and solids
WGKWGK 1 slightly hazardous to water
Safety Information
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin)0.15 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is NovaSyn TG resin (90 µm).
Global Trade Item Number
Catalogue Number GTIN
8.55010.0001 04027269109547
8.55010.0005 04027269109554
8.55010.0025 04027269109561

Documentation

NovaSyn®TGT alcohol resin SDS

Title

Safety Data Sheet (SDS) 

Citations

Title
  • [1] E. Bayer, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium', R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 156.
  • [2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
  • [3] T. M. Fyles, et al. (1976) Can. J. Chem., 54, 935.
  • [4] A. v. Vliet, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
  • [5] A. v. Vliet, et al. in 'Peptides 1992, Proc. 22nd European Peptide Symposium', C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
  • [6] G. Grübler, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium', R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
  • [7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.