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534339 PTPσ Inhibitor, ISP - Calbiochem

A cell-permeable, TAT conjugated peptide derived PTPsigma wedge domain. Binds to PTPsigma and relieves CSPG-mediated inhibition of axonal regrowth following injury.

PTPσ Inhibitor, ISP - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Protein Tyrosine Phosphatase σ Inhibitor, ISP

Primary Target: PTPσ
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇₇H₃₀₆N₆₆O₅₄S₃

Products

Catalogue NumberPackaging Qty/Pack
5.34339.0001 Glass bottle 5 mg
Description
OverviewA cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number534339
Brand Family Calbiochem®
SynonymsProtein Tyrosine Phosphatase σ Inhibitor, ISP
References
ReferencesLang, B. T, et al. 2015. Nature. 518, 404.
Product Information
FormWhite solid
Hill FormulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
Chemical formulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPTPσ
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceNH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.34339.0001 04054839117220

Documentation

PTPσ Inhibitor, ISP - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Lang, B. T, et al. 2015. Nature. 518, 404.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-December-2016 JSW
SynonymsProtein Tyrosine Phosphatase σ Inhibitor, ISP
DescriptionA cell-permeable, TAT conjugated peptide derived from the protein tyrosine phosphatase sigma (PTPsigma) wedge domain that binds to PTPsigma and relieves glial-derived chondroitin sulfate proteoglycan (CSPG)-mediated inhibition. Shown to cross the blood-brain barrier. Does not bind to other CSPG receptors, such as LAR and NgRs. By blocking the PTPsigma-CSPG interaction it abolishes CSPG -mediated inhibition of axonal regrowth and sprouting. Shown to promote adult sensory neuron growth cone (~ 2.5 µM). Restores serotonergic innervations to the spinal cord below the level of injury and promotes progressive functional recovery of both locomotor and urinary systems after spinal cord injury in a rat model (11 µg/day).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇₇H₃₀₆N₆₆O₅₄S₃
Peptide SequenceNH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml) or H₂O (100 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLang, B. T, et al. 2015. Nature. 518, 404.