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  • In-Line PP Filter Holder 47mm - CP9SA1431

    Document Type:
    Certificate of Quality
    Lot Number:
    CP9SA1431
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP6NA4170

    Document Type:
    Certificate of Quality
    Lot Number:
    CP6NA4170
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP5NA1967

    Document Type:
    Certificate of Quality
    Lot Number:
    CP5NA1967
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP7JA3955

    Document Type:
    Certificate of Quality
    Lot Number:
    CP7JA3955
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP0HB4948

    Document Type:
    Certificate of Quality
    Lot Number:
    CP0HB4948
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP1DB0660

    Document Type:
    Certificate of Quality
    Lot Number:
    CP1DB0660
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • In-Line PP Filter Holder 47mm - CP1PB0388

    Document Type:
    Certificate of Quality
    Lot Number:
    CP1PB0388
    Product Catalog Number:
    XX4304700
    Product Catalog Name:
    In-Line Filter Holder 47 mm (In-Line Filter Holder 47 mm)

  • C-FLIP promotes the motility of cancer cells by activating FAK and ERK, and increasing MMP-9 expression. 18414015

    We examined the role of c-FLIP in the motility of HeLa cells. A small interfering RNA (siRNA) directed against c-FLIP inhibited the adhesion and motility of the cells without affecting their growth rate. The long form of c-FLIP (c-FLIPL), but not the short form (c-FLIPS), enhanced adhesion and motility. Downregulation of c-FLIPL with siRNA decreased phosphorylation of FAK and ERK, while overexpression of c-FLIPL increased their phosphorylation. Overexpression of FAK activated ERK, and enhanced the motility of HeLa cells. FRNK, an inhibitory fragment of FAK, inhibited ERK and decreased motility. Inhibition of ERK also significantly suppressed c-FLIPL-promoted motility. Inhibition of ROCK by Y27632 suppressed the c-FLIPL-promoted motility by reducing phosphorylation of FAK and ERK. Overexpression of c-FLIPL increased the expression and secretion of MMP-9, and inhibition of MMP-9 by Ilomastat reduced c-FLIPL- promoted cell motility. A caspase-like domain (amino acids 222-376) was found to be necessary for the c-FLIPL-promoted cell motility. We conclude that c-FLIPL promotes the motility of HeLa cells by activating FAK and ERK, and increasing MMP-9 expression.
    Document Type:
    Reference
    Product Catalog Number:
    06-106
    Product Catalog Name:
    Anti-IGFBP-1 Antibody (Anti-IGFBP-1 Antibody)