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559406 SB 328437 - CAS 247580-43-4 - Calbiochem

559406
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₁H₁₈N₂O₅ 247580-43-4

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559406-1MGCN
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      塑膠安瓿;塑膠針藥瓶 1 mg
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      559406-5MGCN
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          塑膠安瓿;塑膠針藥瓶 5 mg
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          Description
          OverviewA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC50 values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC50 values: 32, 25, and 55 nM, respectively).
          Catalogue Number559406
          Brand Family Calbiochem®
          Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
          References
          ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
          Product Information
          CAS number247580-43-4
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₁H₁₈N₂O₅
          Chemical formulaC₂₁H₁₈N₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCC chemokine receptor-3 (CCR3)
          Primary Target IC<sub>50</sub>38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SB 328437 - CAS 247580-43-4 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          SB 328437 - CAS 247580-43-4 - Calbiochem Certificates of Analysis

          TitleLot Number
          559406

          References

          Reference overview
          White, J.R., et al. 2000. J. Biol. Chem. 275, 36626.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-April-2011 RFH
          Synonyms(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
          DescriptionA highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of 125I-eotaxin and 125I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC50 = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC50 = 38, 35, and 20 nM, respectively).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number247580-43-4
          Chemical formulaC₂₁H₁₈N₂O₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWhite, J.R., et al. 2000. J. Biol. Chem. 275, 36626.