535311
Poly(N-isopropylacrylamide)
Mn ~40,000
Synonym(s):
NIPAM polymer, PNIPAM, Polyacrylamide, polyNIPAM
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About This Item
Linear Formula:
CH3(C6H11NO)nCH3
CAS Number:
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
MDL number:
Product Name
Poly(N-isopropylacrylamide), Mn ~40,000
InChI
1S/C6H11NO/c1-3-5-7-6(8)4-2/h4H,2-3,5H2,1H3,(H,7,8)
SMILES string
CC(C)NC(=O)C=C
InChI key
WDFKEEALECCKTJ-UHFFFAOYSA-N
mol wt
Mn 20,000-60,000
Mn ~40,000
mp
96 °C
Quality Level
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Application
Thermosensitive polymer, can be used to form a hydrogel. Aqueous polymer solution undergoes a phase transition from a soluble to an insoluble state when the temperature is raised to ca. 32 °C.
Physical form
Thermosensitive polymer, hydrogel
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Soichi Takagi et al.
Cell transplantation, 21(2-3), 411-420 (2012-07-17)
The de novo engineering of a uniform hepatocyte sheet in vitro is considered as a novel approach for liver-directed therapeutics. Hepatocytes can be cultured on a temperature-responsive culture dishes coated with poly(N-isopropylacrylamide) (PIPAAm). Following multiple days of culturing, the
Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
A C C Rotzetter et al.
Advanced materials (Deerfield Beach, Fla.), 24(39), 5352-5356 (2012-08-31)
Buildings can be effectively cooled by a bioinspired sweating-like action based on thermoresponsive hydrogels (PNIPAM), which press out their stored water when exceeding the lower critical solution temperature. The surface temperature is reduced by 15 °C compared to that of
Hydrophobic interaction-mediated capture and release of cancer cells on thermoresponsive nanostructured surfaces.
Hongliang Liu et al.
Advanced materials (Deerfield Beach, Fla.), 25(6), 922-927 (2012-11-20)
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