- A convenient TLC method for the identification of local anesthetics.
A convenient TLC method for the identification of local anesthetics.
Die Pharmazie (2006-02-04)
M Schmidt, F Bracher
PMID16454199
ABSTRACT
A TLC method for the separation of seven local anesthetics and the related antiarrhythmic drug procainamide was developed. Spraying the plates with cobalt(II) thiocyanate solution, followed by spraying with Ehrlich's reagent allowed a clear distinction between the drugs, except for the couple articaine/prilocaine. Articaine could be distinguishedfrom prilocaine and other local anesthetics by a colour reaction with copper(II) sulphate solution.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
4-(Dimethylamino)benzaldehyde, puriss. p.a., reag. Ph. Eur., ≥99% (perchloric acid titration)
Sigma-Aldrich
4-(Dimethylamino)benzaldehyde, suitable for histochemical demonstration of nitro blue tetrazolium reduction in neutrophils