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Merck

Y0001236

Econazole

European Pharmacopoeia (EP) Reference Standard

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About This Item

Empirical Formula (Hill Notation):
C18H15Cl3N2O
CAS Number:
Molecular Weight:
381.68
UNSPSC Code:
41116107
NACRES:
NA.24

Product Name

Econazole, European Pharmacopoeia (EP) Reference Standard

SMILES string

Clc1c(ccc(c1)Cl)C(OCc3ccc(cc3)Cl)C[n]2cncc2

InChI

1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2

InChI key

LEZWWPYKPKIXLL-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

econazole

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Application

Econazole EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3


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Scott Thomson et al.
Scientific reports, 7(1), 8247-8247 (2017-08-16)
The soil amoebae Acanthamoeba causes Acanthamoeba keratitis, a severe sight-threatening infection of the eye and the almost universally fatal granulomatous amoebic encephalitis. More effective treatments are required. Sterol biosynthesis has been effectively targeted in numerous fungi using azole compounds that
Wei Qiu et al.
Archives of oral biology, 73, 113-120 (2016-10-21)
The aim of this study was to determine the inhibitory effect of eight antifungal drugs on S. mutans growth, biofilm formation and virulence factors. The actions of antifungal drugs on S. mutans were determined by recovery plates and survival kinetic
Azza A Mahmoud et al.
International journal of pharmaceutics, 413(1-2), 229-236 (2011-05-05)
Development of efficient ocular delivery nanosystems remains a major challenge to achieve sustained therapeutic effect. The purpose of this work was to develop chitosan nanoparticles using sulfobutylether-β-cyclodextrin (SBE-β-CD) as polyanionic crosslinker and to investigate the potential of using those nanostructures
Poonam Verma et al.
Nanomedicine : nanotechnology, biology, and medicine, 8(4), 489-496 (2011-08-16)
This project aimed at developing nanovesicles of econazole nitrate (EN) and formulating them as a suitable dermatological gel for improved therapeutic efficacy, better dispersity, and good storage stability. Ethosomes were prepared by cold method and evaluated for the mean diameter
R C Heel et al.
Drugs, 16(3), 177-201 (1978-09-01)
Econazole1 is a recently introduced imidazole antifungal agent which is very closely related structurally to another imidazole derivative, miconazole. For local application the nitrate salt of econazole is used, while in preliminary investigations of systemic use in a few patients

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