19-130
Okadaic Acid (sodium salt)
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About This Item
UNSPSC Code:
12352106
eCl@ss:
32160405
NACRES:
NA.41
form:
solid
form
solid
Quality Level
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
shipped in
wet ice
Application
Suitable for use as an inhibitor of serine/threonine-specific protein phosphatases.
Preparation Note
Lyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C
Analysis Note
Routinely evaluated as an inhibitor in a kinase assay.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
Redpath, N T and Proud, C G
The Biochemical Journal, 262, 69-75 (1989)
F M Amara et al.
The Journal of biological chemistry, 271(33), 20126-20131 (1996-08-16)
Mammalian ribonucleotide reductase is a highly regulated activity essential for DNA synthesis and repair. The 3'-untranslated region (3'-UTR) of mammalian ribonucleotide reductase R2 mRNA has been implicated in the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate-mediated stabilization of mouse BALB/c 3T3 R2 message. We
Okadaic acid. Protein phosphatase inhibition and muscle contractile effects.
Takai, A
Journal of Muscle Research and Cell Motility, 9, 563-565 (1988)
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Wheat, W H, et al.
Molecular and cellular biology, 14, 5881-5890 (1994)
E G Mimnaugh et al.
The Journal of biological chemistry, 270(48), 28654-28659 (1995-12-01)
The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs its cellular trafficking and negatively regulates its kinase activity. Here we report that the serine/threonine phosphatase inhibitor, okadaic acid, destabilized the
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 19-130 | 04053252731921 |
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