F0931
Factor Va human
≥1500 units/mg protein
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Form:
solution
Biological source:
human
Mol wt:
168 kDa
Servicio técnico
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Permítanos ayudarleGeneral description
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.
Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.
Biochem/physiol Actions
Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.
Physical form
Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2
Other Notes
One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.
View this factors role in the Coagulation Cascade
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Less Common Congenital Disorders of Hemostasis
Consultative Hemostasis and Thrombosis, 60-78 (2013)
The factor V activation paradox
Orfeo T, et al.
The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)
Eliza A Ruben et al.
Blood, 137(22), 3137-3144 (2021-03-09)
Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. We solved the cryogenic electron microscopy (cryo-EM) structures of