H3160
Hydrocortisone
meets USP testing specifications
Sinónimos:
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione, 17-Hydroxycorticosterone, 4-Pregnene-11β,17α,21-triol-3,20-dione, Cortisol, Kendall’s compound F, Reichstein’s substance M
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biological source
plant (wild yam)
agency
USP/NF, meets USP testing specifications
assay
97.0-102.0% dry basis
form
powder
potency
0.004-0.005 μg/mL
mp
211-214 °C (lit.)
solubility
water: soluble 0.28 g/L at 25 °C
application(s)
pharmaceutical (small molecule)
SMILES string
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO
InChI
1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI key
JYGXADMDTFJGBT-VWUMJDOOSA-N
Gene Information
human ... ABCB1(5243), CYP3A4(1576), NR3C1(2908), SERPINA6(866)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126)
rat ... Ar(24208), Nr3c1(24413)
Application
- Exploring Microemulsion Systems for the Incorporation of Glucocorticoids into Bacterial Cellulose: This research presents a novel method for embedding hydrocortisone into bacterial cellulose using microemulsion systems, highlighting its potential for creating anti-inflammatory wound dressings, a significant advancement in pharmaceutical design and material science (Zahel et al., 2024).
- Research progress in the treatment of chronic fatigue syndrome through interventions targeting the hypothalamus-pituitary-adrenal axis: This review discusses the role of hydrocortisone in treating chronic fatigue syndrome by modulating the hypothalamus-pituitary-adrenal axis, providing a comprehensive overview of its therapeutic applications in endocrinology (Zhang and Wang, 2024).
Biochem/physiol Actions
Physical form
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signalword
Danger
hcodes
Hazard Classifications
Repr. 1A - STOT RE 2
Clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
target_organs
Adrenal gland,Bone marrow
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