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504778 Nebivolol Hydrochloride - CAS 152520-56-4 - Calbiochem

504778
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
152520-56-4C₂₂H₂₅F₂NO₄ • HCl
Description
Overview

This product has been discontinued.



A competitive, highly selective β1-adrenoceptor antagonist (more than 40-fold selective for β1 than β2; Ki1 and β2, respectively). The most β1-selective chemical of the β-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36 µM in renal arteries).

Catalogue Number504778
Brand Family Calbiochem®
Synonymsrel-(aR,aʹR,2R,2ʹS)-a,aʹ-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride, β₁-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol
References
ReferencesPauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
Georgescu, A., et al. 2008. Pharmacology 81, 110.
Product Information
CAS number152520-56-4
FormWhite powder
Hill FormulaC₂₂H₂₅F₂NO₄ • HCl
Chemical formulaC₂₂H₂₅F₂NO₄ • HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target→₁-adrenoceptor
Primary Target K<sub>i</sub>0.88 and 44 for →₁ and →₂, respectively.
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at-20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
504778 0

Documentation

Nebivolol Hydrochloride - CAS 152520-56-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Pauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
Georgescu, A., et al. 2008. Pharmacology 81, 110.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-May-2013 JSW
Synonymsrel-(aR,aʹR,2R,2ʹS)-a,aʹ-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride, β₁-Adrenoceptor Antagonist, Nebivolol Hydrochloride, Nebilet, R-65824, Narbivolol
DescriptionA competitive, highly selective ?1-adrenoceptor antagonist (more than 40-fold selective for ?1 than ?2; Ki = 0.88 and 44 for ?1 and ?2, respectively). The most ?1-selective chemical of the ?-blockers tested so far. Used for treatment of essential hypertension and highly cardioselective. Induces mild vasodialation via a nitric oxide- and cGMP-depedent pathways (EC50 = 11.36 ?M in renal arteries).
FormWhite powder
CAS number152520-56-4
Chemical formulaC₂₂H₂₅F₂NO₄ • HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (20 mg/m)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at-20°C.
Toxicity Standard Handling
ReferencesPauwels, P., et al. 1988. Mol. Pharmacol. 34, 843.
Georgescu, A., et al. 2007. Eur. J. Pharmacol. 570, 149.
Georgescu, A., et al. 2008. Pharmacology 81, 110.