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LiChrospher ADS

LiChrospher® ADS – For direct on-line sample preparation of untreated bio fluids

LiChrospher® ADS for on-line sample preparation

HPLC analysis of low molecular compounds in biological samples can lead to an irreversible increase in back pressure, to loss of capacity, to a drop in selectivity, and, in the long run, to serious damage of  HPLC columns. LiChrospher® ADS is especially designed to take care of this problem.

This on-line sample preparation method enables the direct extraction and enrichment of hydrophobic, low molecular analytes from untreated samples. Such samples can be haemolysed blood, plasma, serum, milk, salivary fluid, fermentation broth, supernatants of cell cultures and tissue as well as food homogenates.

LiChrospher® ADS allows fully automated sample preparation prior to the analytes being separated in the column. This allows untreated bio-fluids to be directly injected with no negative effects on either the column or the results achieved.  

Your benefits:
  • Time-saving
  • Cost-effective
  • Easy-to-handle
 

LiChrospher® ADS for on-line sample preparation

The enrichment is based on two chromatographic processes: reversed phase and size exclusion chromatography. This is due to LiChrospher® ADS sorbents, which are spherical silica gel particles (25µm) with DIOL modification on the exterior surface and alkyl modifications on the surface of the interior pores. Depending on the hydrophobicity of the analyte, three types of precolumns are available: C-4, C-8 and C-18.


Three types of ADS pre-columns are available with different hydrophobicity and retention and extraction properties for non-polar sample compounds:

 

 

Applications with LiChospher® ADS to support you and your work:

021311 Cancer medication (Standards) - separation of Doxorubicin, Epirubicin, Daunorubicin, Idarubicin - using a LiChrospher® RP select B column - fluorescence detection
 981271 Cancer medication in Liver tumor - separation of 4'-Epirubicin hydrochloride - using a LiChrospher® RP select B column
 021312 Cancer medication in Urine - separation of Epirubicin, Epirubicinol - using a LiChrospher® RP select B column -fluorescence detection
 981272 Cancer medication in Plasma - separation of 4'-Epirubicin hydrochloride - using a LiChrospher® RP select B column
 981270 Cancer medication in Plasma - separation of Epirubicin, Epirubicinol, 3 Epirubicin aglycon, Epirubicinol aglycon, 7- Deoxyepirubicinol aglycon - using a LiChrospher® RP select B column
 960789 Cancer medication in Plasma - separation of Epirubicin, Epirubicinol, Epirubicin, Epirubicinol aglycon, 7-Deoxyepirubicinol - using a LiChrospher® RP select B column - fluorescence detection
 981273 Cancer medication in Urine - separation of 4'-Epirubicin hydrochloride - using a LiChrospher® RP select B column

Haven’t found the application you were looking for, or want to publish one of your own? Please review our Analytical Application Finder,  or contact us .

© Merck KGaA, Darmstadt, Deutschland, 2014


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