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Merck

48-682MAG

MILLIPLEX® Bcl-2 Family Apoptosis Panel Signaling Panel

Premixed Human Bcl-2 Family Apoptosis Panel 1 6-Plex Cell Signaling Panel

Synonym(s):

6-plex apoptosis assay, Bcl-2 assay, Bcl-2 family proteins, anti-apoptotic proteins, apoptosis markers, apoptosis multiplex panel, cell death biomarkers, mitochondrial apoptosis, pro-apoptotic proteins

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About This Item

NACRES:
NA.47
UNSPSC Code:
12161503

Key Documents

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Product Name

MILLIPLEX® Bcl-2 Family Apoptosis Panel Signaling Panel, Premixed Human Bcl-2 Family Apoptosis Panel 1 6-Plex Cell Signaling Panel

Quality Level

100

species reactivity

human

manufacturer/tradename

Milliplex®

packaging

1 ea of

technique(s)

multiplexing: suitable

input

cell lysate

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Preparation Note

Recommended storage for kit components is 2 - 8°C.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany

Biochem/physiol Actions

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Simultaneous detection of 6 key Bcl-2 family proteins
  • Enables profiling of pro- and anti-apoptotic markers
  • Supports studies on mitochondrial-mediated apoptosis
  • Multiplex format conserves sample and increases throughput
  • Verified for use with human cell lysates

General description

BAK and BAX promote mitochondrial outer membrane permeabilization, while BCL-2, BCL-W, BCL-XL, and MCL-1 inhibit apoptosis. Together, these proteins regulate the intrinsic apoptotic pathway and determine cell fate under stress conditions.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 6 analytes in human cell lysate samples.

Analytes Included: BAD (pS112), BAD (Total), BAX, Bcl-xL/BAD, BIM, Mcl-1/BIM

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).

signalword

Danger

Storage Class

10 - Combustible liquids

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
48-682MAG04054839444272

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