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Merck

48-683MAG

MILLIPLEX® Bcl-2 Family Apoptosis Panel Signaling Panel

Premixed Human Bcl-2 Family Apoptosis Panel 2 4-Plex Cell Signaling Panel

Synonym(s):

4-plex apoptosis panel, Bcl-2 family assay, Bcl-2 signaling, apoptosis detection, apoptosis multiplex assay, cancer apoptosis biomarkers, cell death analysis, intrinsic apoptosis pathway, pro-survival proteins

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About This Item

NACRES:
NA.47
UNSPSC Code:
12161503

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Product Name

MILLIPLEX® Bcl-2 Family Apoptosis Panel Signaling Panel, Premixed Human Bcl-2 Family Apoptosis Panel 2 4-Plex Cell Signaling Panel

Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

packaging

1 ea of

technique(s)

multiplexing: suitable

input

cell lysate

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible.

Preparation Note

Recommended storage for kit components is 2 - 8°C.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
MAPMATE is a trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Measures 4 additional Bcl-2 family proteins in a single assay
  • Complements Bcl-2 Family Apoptosis Panel 1 for expanded apoptosis profiling
  • Ideal for studying intrinsic apoptotic pathways
  • High sensitivity and reproducibility
  • Suitable for limited sample volumes and high-throughput analysis

General description

BAD, BID, and BIM are pro-apoptotic BH3-only proteins that initiate apoptosis by antagonizing anti-apoptotic Bcl-2 members. BCL-B functions as a pro-survival protein, contributing to the balance of apoptotic signaling.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 4 analytes in human cell lysate samples.

Analytes Included: Bcl-2, Bcl-xL, Mcl-1, NOXA/Mcl-1

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).

signalword

Danger

Storage Class

10 - Combustible liquids

wgk

WGK 3

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - ED ENV 1 - Eye Dam. 1 - Skin Irrit. 2

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Global Trade Item Number

SKUGTIN
48-683MAG04054839444289

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