8.52095
Fmoc-Lys(Mca)-OH
≥97.0% (HPLC), for peptide synthesis, Novabiochem®
別名:
Fmoc-Lys(Mca)-OH, N-α-Fmoc-N-ε-7-methoxycoumarin-4-acetyl-L-lysine
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この商品について
実験式（ヒル表記法）:
C33H32N2O8
CAS番号:
分子量:
584.62
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
製品名
Fmoc-Lys(Mca)-OH, Novabiochem®
Quality Segment
product line
Novabiochem®
assay
≥97% (TLC), ≥97.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
−20°C
SMILES string
N([C@@H](CCCCNC(=O)Cc4c5c([o][c](c4)=O)cc(cc5)OC)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C33H32N2O8/c1-41-21-13-14-22-20(17-31(37)43-29(22)18-21)16-30(36)34-15-7-6-12-28(32(38)39)35-33(40)42-19-27-25-10-4-2-8-23(25)24-9-3-5-11-26(24)27/h2-5,8-11,13-14,17-18,27-28H,6-7,12,15-16,19H2,1H3,(H,34,36)(H,35,40)(H,38,39)/t28-/m0/s1
InChI key
BWJJONDPLYEAMC-NDEPHWFRSA-N
General description
A modified lysine derivative for the preparation of fluorogenically-labeled peptides by Fmoc SPPS [1]. The Mca group fluoresces at 405 nm when stimulated at 340 nm, and is most commonly used in conjunction with Dabcyl and 2,4-dinitrophenyl quenching groups. Recently, Fmoc-Lys(Mca)-OH has been used to prepare lanthanide-based luminescent proteins by native chemical ligation [2]. Lys(Mca) was found to be stable to HF cleavage conditions used to synthesize the thioester fragments needed for ligation.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Chromogenic Labeling of Synthetic Peptides
Literature references
[1] J. L. Lauer-Fields, et al. (2001) Biochemistry, 40, 5795.
[2] C. F. W. Becker, et al. (2004) Bioconjugate Chem., 15, 1118.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Chromogenic Labeling of Synthetic Peptides
Literature references
[1] J. L. Lauer-Fields, et al. (2001) Biochemistry, 40, 5795.
[2] C. F. W. Becker, et al. (2004) Bioconjugate Chem., 15, 1118.
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Water (K. F.): ≤ 2.0 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Water (K. F.): ≤ 2.0 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Replaces: 04-12-1233
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable