CH2900011
Calcium Folinate Hydrate crystalline / Leucovorin Calcium crystalline
Ph. Eur., USP
Sinónimos:
Folinic acid calcium salt, Calcii Folinas, Calcium Folinate, Leucovorin Calcium, Calcium folinate
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Fórmula empírica (notación de Hill):
C20H21CaN7O7
Número CAS:
Peso molecular:
511.50
MDL number:
UNSPSC Code:
41116107
Servicio técnico
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Permítanos ayudarlebiological source
synthetic
Quality Segment
grade
GMO free, GMP, Halal, Kosher
agency
Ph. Eur., USP
form
powder
application(s)
pharmaceutical
solid formulation
storage temp.
2-8°C
SMILES string
[Ca+2].[nH]1c2c([c](nc1N)=O)N(C(CN2)CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])C=O
InChI
1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
InChI key
KVUAALJSMIVURS-ZEDZUCNESA-L
General description
We provide industry-leading production know-how and comprehensive regulatory support for high-quality APIs, backed by nearly 200 years of experience. From a complete portfolio of innovative folates to custom synthesis, our customized and scalable solutions meet your specific production needs. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.
Application
Calcium Folinate Hydrate crystalline has three main clinical applications:
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.
1) First line treatment for colorectal cancer: In combination with the anticancer drug 5-fluorouracil (5-FU), Irinotecan, Cisplatin or Oxaliplatin, and its derivatives. Calcium Folinate is a modulator of 5-FU and enhances its efficacy in cancer chemotherapy.
2) Treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis as a rescue therapy to reduce the toxic side effects of intermediate or high doses of methotrexate.
3) Treatment of anemia caused by folate deficiency.
Packaging
Customized packaging possible
Legal Information
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Clase de almacenamiento
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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