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Merck

HCVD2MAG-67K

MILLIPLEX® Human Cardiovascular Disease Panel

Configurable Human CVD 10-Plex Panel 2

Synonym(s):

CVD assay snapshot, CVD multiplex product sheet, cardiovascular biomarker listing, cardiovascular biomarker profile, coagulation and inflammation detection kit, human CVD assay overview, human cardiovascular panel summary, human cardiovascular research tool, human vascular biomarker info, vascular inflammation biomarker panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Product Name

MILLIPLEX® Human Cardiovascular Disease Panel, Configurable Human CVD 10-Plex Panel 2

species reactivity

human

manufacturer/tradename

Milliplex®

Quality Level

200

packaging

1 ea of

assay range

accuracy: 88%
(Myoglobin)
accuracy: 90%
(P-selectin)
accuracy: 98%
(GDF-15)
standard curve range: 0.0005-2.5 ng/mL
(GDF-15)
standard curve range: 0.012-50 ng/mL
(Lipocalcin-2/NGAL)
standard curve range: 0.024-100 ng/mL
(Myoglobin & MPO)
standard curve range: 0.085-350 ng/mL
(sICAM-1)
standard curve range: 0.122-500 ng/mL
(sVCAM-1)
standard curve range: 0.244-1,000 ng/mL
(D-dimer, SAA & P-selectin)
standard curve range: 1.221-5,000 ng/mL
(ADAMTS 13)
inter-assay cv: <20%
intra-assay cv: <15%

technique(s)

multiplexing: suitable

input

serum plasma (Cell culture, cell culture supernatants)

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Features:
  • Targets biomarkers involved in vascular inflammation, endothelial activation, and coagulation
  • Includes 10 analytes relevant to cardiovascular risk, oxidative stress, and immune response
  • Multiplex format enables simultaneous detection from minimal sample volume
  • Compatible with human serum and plasma samples
  • Designed for research in atherosclerosis, thrombosis, acute coronary syndromes, and systemic inflammation
Benefits:
  • Provides a comprehensive profile of cardiovascular and inflammatory biomarkers
  • Supports investigation of vascular injury, immune activation, and thrombotic mechanisms
  • Facilitates evaluation of therapeutic interventions and biomarker-based risk assessment
  • Enables high-throughput analysis with reduced sample and reagent use
  • Delivers reproducible, sensitive results for translational and clinical research

General description

Cardiovascular disease is closely linked to inflammation, endothelial dysfunction, oxidative stress, and coagulation abnormalities. This set of biomarkers—ADAMTS13, D-dimer S, GDF15, sICAM-1, Myeloperoxidase (MPO), Myoglobin, NGAL/Lipocalin-2, sP-Selectin, Serum Amyloid A, and sVCAM-1—captures key indicators of vascular injury, immune activation, and thrombotic risk. These analytes are widely studied in the context of atherosclerosis, acute coronary syndromes, and systemic inflammation, making them highly relevant for translational and clinical cardiovascular research.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 10 analytes in human serum, plasma, or cell culture supernatants.

Analytes included: ADAMTS13, D-dimer S, GDF15, sICAM-1, Myeloperoxidase (MPO), Myoglobin, NGAL/Lipocalin-2, sP-Selectin, Serum Amyloid A, sVCAM-1Note: D-Dimer cannot be measured in plasma samples.

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Estefania Simoes et al.
International journal of obesity (2005), 45(4), 879-887 (2021-02-03)
Childhood overweight and obesity are a global concern, with prevalence rising dramatically over the last decades. The condition is caused by an increase in energy intake and reduction of physical activity, leading to excessive fat accumulation, followed by systemic chronic
Lilliam Rocha-Penha et al.
Hypertension (Dallas, Tex. : 1979), 69(6), 1173-1180 (2017-05-04)
Elevated levels of myeloperoxidase have been demonstrated in women with preeclampsia where it may contribute to endothelial dysfunction mediated, in part, by nitric oxide impairment. In this study, we investigated myeloperoxidase in hypertensive disorders of pregnancy and its contribution to
Alberto Soriano-Maldonado et al.
Journal of clinical medicine, 7(12) (2018-11-28)
This study assessed the effect of 12-week aerobic exercise on arterial stiffness (primary outcome), inflammation, oxidative stress, and cardiorespiratory fitness (secondary outcomes) in women with systemic lupus erythematosus (SLE). In a non-randomized clinical trial, 58 women with SLE were assigned
Emanuele Marzetti et al.
Frontiers in medicine, 1, 27-27 (2015-01-17)
Chronic, low-grade inflammation and declining physical function are hallmarks of the aging process. However, previous attempts to correlate individual inflammatory biomarkers with physical performance in older people have produced mixed results. Given the complexity of the inflammatory response, the simultaneous
Riccardo Calvani et al.
Journal of cachexia, sarcopenia and muscle, 8(1), 69-77 (2016-11-30)
Chronic inflammation, changes in body composition, and declining physical function are hallmarks of the ageing process. The aim of the present study was to provide a preliminary characterisation of the relationship among these age-related phenomena via multivariate modelling. Thirty-five old
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Protocol- HCVD2MAG-67K
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Global Trade Item Number

SKUGTIN
HCVD2MAG-67K-0704053252798863
HCVD2MAG-67K-0504053252798849
HCVD2MAG-67K-0804053252798870
HCVD2MAG-67K-0904053252798887
HCVD2MAG-67K-1004053252798894
HCVD2MAG-67K-0204053252798818
HCVD2MAG-67K-0304053252798825
HCVD2MAG-67K-0404053252798832
HCVD2MAG-67K-0104053252798801
HCVD2MAG-67K-0604053252798856

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