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A propos de cet article
UNSPSC Code:
41116126
NACRES:
NA.84
Nom du produit
MILLIPLEX® Human Neurodegenerative Autoantibody Magnetic Bead Panel,
Quality Level
description
Simultaneously analyze up to 25 autoantibodies in a bead-based assay using Luminex® technology, in human serum, plasma, and cerebrospinal fluid (CSF)
quality
200
species reactivity
human
manufacturer/tradename
Milliplex®
technique(s)
multiplexing: suitable
input
serum
plasma
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
General description
Neurodegenerative autoantibodies are immune system-produced antibodies that mistakenly attack the body′s own nervous system proteins, disrupting synaptic function and causing inflammation and neuronal damage. They target essential proteins like synaptic proteins, neuronal antigens, cell surface receptors, and aggregation-prone proteins. Detecting these autoantibodies in blood or cerebrospinal fluid (CSF) can provide valuable insights into the autoimmune processes linked to neurodegenerative diseases. Research on autoantibodies enhances our understanding of serious neurological disorders and may lead to new therapeutic options.
Application
MILLIPLEX® Qualified assays undergo rigourous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 25 neurodegenerative autoantibodies in human serum, plasma, and CSF.
Analytes included: anti-α-synuclein, anti-AChR (acetylcholine receptor), anti-AGNA (Anti-Glial Nuclear Antibody, SOX1), anti-Ago2 (Su), anti-CRYAB (α B-crystallin), anti-AMPA-R, anti-Amphiphysin, anti-ANNA2 (Ri)/NOVA1, anti-AQP4 (aquaporin-4), anti-Aβ42, anti-CRMP5 (Collapsin Response Mediater Protein 5), anti-DPPX, anti-DRD2 (Dopamine D2 Receptor), anti-ELAVL4 (HuD), anti-GFAP (Glial Fibrillary Acidic Protein), anti-MBP (Myelin Basic Protein), anti-C1q, anti-mGluR1, anti-MOG (Myelin Oligodendrocyte Glycoprotein), anti-NF-L (Neurofilament light chain), anti-NMDAR1, anti-NRXN3 (neurexin-3), anti-PCA1 (Yo)/CDR2, anti-PNMA1 (Ma1), and anti-tTau
Assay Characteristics: Refer to kit protocol for assay cross-reactivity and sensitivity.
Analytes included: anti-α-synuclein, anti-AChR (acetylcholine receptor), anti-AGNA (Anti-Glial Nuclear Antibody, SOX1), anti-Ago2 (Su), anti-CRYAB (α B-crystallin), anti-AMPA-R, anti-Amphiphysin, anti-ANNA2 (Ri)/NOVA1, anti-AQP4 (aquaporin-4), anti-Aβ42, anti-CRMP5 (Collapsin Response Mediater Protein 5), anti-DPPX, anti-DRD2 (Dopamine D2 Receptor), anti-ELAVL4 (HuD), anti-GFAP (Glial Fibrillary Acidic Protein), anti-MBP (Myelin Basic Protein), anti-C1q, anti-mGluR1, anti-MOG (Myelin Oligodendrocyte Glycoprotein), anti-NF-L (Neurofilament light chain), anti-NMDAR1, anti-NRXN3 (neurexin-3), anti-PCA1 (Yo)/CDR2, anti-PNMA1 (Ma1), and anti-tTau
Assay Characteristics: Refer to kit protocol for assay cross-reactivity and sensitivity.
Features and Benefits
- Versatile Analyte Selection: Customize your research with the ability to select from a panel of 25 neurodegenerative autoantibodies, allowing for tailored solutions that address specific research questions.
- All-in-One Kit Format: Each kit includes all necessary reagents and an intuitive protocol, simplifying the assay process and reducing the need for multiple kits, which saves time and resources.
- High Precision and Specificity: Achieve reliable results with demonstrated precision (<10% intra-assay CV and <15% inter-assay CV) and minimal cross-reactivity, ensuring the accuracy and trustworthiness of your findings.
- Unique Neurodegenerative Disease Research Tool: This first-of-its-kind assay enables valuable insights into the autoimmune mechanisms underlying neurodegenerative diseases.
Preparation Note
Recommended storage for kit components is 2-8˚C.
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1
Classe de stockage
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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