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Merck

HNS2MAG-95K

MILLIPLEX® Human Neuroscience Panel

Configurable Human Neuroscience 6-Plex Panel 2

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000

Product Name

MILLIPLEX® Human Neuroscience Panel, Configurable Human Neuroscience 6-Plex Panel 2

species reactivity

human

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 124%
(Neurogranin)
accuracy: 84%
(FABP3)
accuracy: 85%
(ApoE4)
accuracy: 94%
(TREM2)
accuracy: 97%
(Angiogenin)
sensitivity: 11.0 pg/mL
(MinDC + 2SD; TREM2)
sensitivity: 14.3 pg/mL
(MinDC + 2SD; FABP3)
sensitivity: 162.8 pg/mL
(MinDC + 2SD; ApoE4)
sensitivity: 19.9 pg/mL
(MinDC + 2SD; Neurogranin)
sensitivity: 5.8 pg/mL
(MinDC + 2SD; Angiogenin)
sensitivity: 6.1 pg/mL
(MinDC + 2SD; Ferritin)
standard curve range: 15-50,000 pg/mL
(TREM2)
standard curve range: 2-10,000 pg/mL
(Angiogenin)
standard curve range: 24-100,000 pg/mL
(FABP3)
standard curve range: 244-1,000,000 pg/mL
(ApoE4)
standard curve range: 5-20,000 pg/mL
(Neurogranin)
standard curve range: 6-25,000 pg/mL
(Ferritin)
inter-assay cv: <10%
intra-assay cv: <5%
(Angiogenin)
inter-assay cv: <10%
intra-assay cv: <5%
(FABP3)
inter-assay cv: <10%
intra-assay cv: <5%
(TREM2)
inter-assay cv: <15%
intra-assay cv: <10%
(Ferritin)
inter-assay cv: <15%
intra-assay cv: <10%
(Neurogranin)
inter-assay cv: <15%
intra-assay cv: <5%
(ApoE4)

technique(s)

multiplexing: suitable

input

cerebrospinal fluid(s) (CSF)
serum
cell culture supernatant

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Luminex is a registered trademark of Luminex Corp
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cerebrospinal fluid (CSF).Analytes included: Angiogenin, Apolipoprotein E4 (ApoE4), Fatty Acid Binding Protein 3 (FABP3), Ferritin, Neurogranin, Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).Note: When testing serum/plasma samples, Angiogenin and ApoE4 require a 1:200 dilution while FABP3, Ferritin, Neurogranin and TREM2 require a 1:10 dilution. These sets of analytes should not be multiplexed together and instead run as separate assays. If testing CSF samples, all analytes can be plexed together.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Comprehensive Pathway Coverage: Simultaneously quantify six critical neurological biomarkers spanning synaptic function, neuroinflammation, and lipid metabolism, providing a complete picture of neurodegeneration in a single assay.
Dual-Fluid Versatility: Analyze both challenging CSF samples and accessible blood samples with exceptional sensitivity, enabling flexible study designs while addressing the critical need for blood-based neurological biomarkers.
Research-Ready Reliability: Trust in consistent, reproducible results with < 5% intra-assay precision for most analytes and rigorous cross-reactivity testing, so your neuroscience discoveries are built on solid data foundations.
Streamlined Neuroscience Workflow: Eliminate the complexity of multiple single-analyte assays with our comprehensive 6-plex format, accelerating your research timeline and maximizing your sample utility for breakthrough neurological insights.

General description

Neurogranin plays a pivotal role in learning and memory by modulating synaptic plasticity. TREM2, expressed on microglia, governs immune responses and facilitates amyloid clearance. ApoE4, a major genetic risk factor for Alzheimer′s, influences lipid metabolism and neuronal repair. FABP3 marks neuronal damage, while ferritin and angiogenin reflect neuroinflammatory activity and vascular health—together painting a multifaceted picture of brain dysfunction.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Maciej Dulewicz et al.
Journal of clinical medicine, 10(19) (2021-10-14)
Synaptic loss and dysfunction are one of the earliest signs of neurodegeneration associated with cognitive decline in Alzheimer's disease (AD). It seems that by assessing proteins related to synapses, one may reflect their dysfunction and improve the understanding of neurobiological
Frederic Brosseron et al.
Journal of neurochemistry, 157(6), 2210-2224 (2020-09-08)
There is growing evidence that promising biomarkers of inflammation in Alzheimer´s disease (AD) and other neurodegenerative diseases correlate strongest to levels of tau or neurofilament, indicating an inflammatory response to neuronal damage or death. To test this hypothesis, we investigated

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Global Trade Item Number

SKUGTIN
HNS2MAG-95K-0704054839523403
HNS2MAG-95K-0304054839523366
HNS2MAG-95K-0404054839523373
HNS2MAG-95K-0104054839523342
HNS2MAG-95K-0604054839523397
HNS2MAG-95K-0504054839523380
HNS2MAG-95K-0204054839523359

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