HPRTKMAG-01K
MILLIPLEX® RTK Phosphoprotein Signaling Panel
Configurable RTK Phosphoprotein 16-Plex Cell Signaling Panel
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
Product Name
MILLIPLEX® RTK Phosphoprotein Signaling Panel, Configurable RTK Phosphoprotein 16-Plex Cell Signaling Panel
species reactivity
human
Quality Level
packaging
pkg of 1 ea
manufacturer/tradename
Milliplex®
technique(s)
multiplexing: suitable
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 16 analytes in cell lysate samples.Analytes Included: phosphorylated (panTyr) c-Kit, c-Met/HGFR, EGFR, ErbB2/HER2, ErbB3/HER3 , ErbB4/HER4 , FGFR1 , FLT3 , IGF-1R, M-CSFR, PDGFRβ, TIE1, TIE2, VEGFR1, VEGFR2, and VEGFR3Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, buffer compatibility, lysate control, and recommended loading control (MAPmate™ Control Assays).
Disclaimer
For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
• Simultaneously detect multiple phosphorylated receptor tyrosine kinases (RTKs) involved in cell growth, survival, and differentiation• Includes key RTKs such as EGFR, HER2, VEGFR, PDGFR, and others• Magnetic bead-based format ensures reproducibility and efficient processing• Compatible with cell lysates from cancer, immunology, and signal transduction studies• Ideal for oncology, drug discovery, and receptor signaling research• Fast, convenient alternative to Western Blotting and immunoprecipitation procedures
General description
This panel targets phosphorylated receptor tyrosine kinases (RTKs), which are essential mediators of cell signaling in response to growth factors and cytokines. RTKs such as EGFR, HER2, VEGFR, and PDGFR regulate pathways involved in cell proliferation, survival, and differentiation. Aberrant RTK activation is associated with cancer, making this panel valuable for oncology and signal transduction research.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
Storage Class
10 - Combustible liquids
Certificates of Analysis (COA)
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Adam Stewart et al.
Molecular cancer therapeutics, 18(8), 1396-1404 (2019-07-03)
It is increasingly appreciated that drug response to different cancers driven by the same oncogene is different and may relate to differences in rewiring of signal transduction. We aimed to study differences in dynamic signaling changes within mutant KRAS (KRAS
Elizabeth A Coker et al.
Molecular cancer therapeutics, 21(6), 1020-1029 (2022-04-04)
We hypothesize that the study of acute protein perturbation in signal transduction by targeted anticancer drugs can predict drug sensitivity of these agents used as single agents and rational combination therapy. We assayed dynamic changes in 52 phosphoproteins caused by
Ahmet Acar et al.
Nature communications, 11(1), 1923-1923 (2020-04-23)
Drug resistance mediated by clonal evolution is arguably the biggest problem in cancer therapy today. However, evolving resistance to one drug may come at a cost of decreased fecundity or increased sensitivity to another drug. These evolutionary trade-offs can be
Global Trade Item Number
| SKU | GTIN |
|---|---|
| HPRTKMAG-01K-05 | 04054839035289 |
| HPRTKMAG-01K-13 | 04054839035678 |
| HPRTKMAG-01K-17 | 04054839035715 |
| HPRTKMAG-01K-16 | 04054839035708 |
| HPRTKMAG-01K-04 | 04054839035272 |
| HPRTKMAG-01K-18 | 04054839035722 |
| HPRTKMAG-01K-08 | 04054839035623 |
| HPRTKMAG-01K-12 | 04054839035661 |
| HPRTKMAG-01K-14 | 04054839035685 |
| HPRTKMAG-01K-09 | 04054839035630 |
| HPRTKMAG-01K-07 | 04054839035616 |
| HPRTKMAG-01K-01 | 04054839035241 |
| HPRTKMAG-01K-11 | 04054839035654 |
| HPRTKMAG-01K-10 | 04054839035647 |
| HPRTKMAG-01K-03 | 04054839035265 |
| HPRTKMAG-01K-02 | 04054839035258 |
| HPRTKMAG-01K-06 | 04054839035296 |
| HPRTKMAG-01K-15 | 04054839035692 |
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