MGAMMAG-300E
MILLIPLEX® Mouse Immunoglobulin Isotyping Panel
Mouse IgE Singleplex Kit
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.47
eCl@ss:
32161000
Product Name
MILLIPLEX® Mouse Immunoglobulin Isotyping Panel, Mouse IgE Singleplex Kit
species reactivity
mouse
manufacturer/tradename
Milliplex®
Quality Level
packaging
1 ea of
assay range
accuracy: 82%
sensitivity: 0.16 ng/mL
standard curve range: 0.8-3500 ng/mL
inter-assay cv: <10%
intra-assay cv: <5%
technique(s)
multiplexing: suitable
input
cell lysate
culture supernatant(s)
detection method
fluorometric (Luminex® xMAP® technology)
shipped in
wet ice
storage temp.
2-8°C
Legal Information
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
General description
Found only in mammals, Immunoglobulin E (IgE) plays an essential role in allergic reactions and is predominantly associated with type 1 hypersensitivity. IgE is the least abundant immunoglobulin isotype in normal or topic mammals, present at only 0.05% of IgG serum concentrations. It can trigger robust immune reactions, with up to 10 times the typical level detected in the serum of atopic mammals, although increased levels occur only in approximately 50% of mammals with allergic disorders. IgE binds with high affinity to FcRI, found primarily on mast cells and basophils, priming the cells to recognize specific antigens. Once primed and with repeated exposure to the same antigen, these cells release molecules such as histamines, prostaglandins, and leukotrienes, resulting in an “allergic reaction”.
Application
MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Analyze IgE in mouse serum, plasma, tissue/cell lysates, and cell culture supernatants.
Analytes included: IgE
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Analytes included: IgE
Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.
Disclaimer
For research use only. Not for use in diagnostic procedures.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Label License/Sticker for Assay Product:
By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.
Features and Benefits
Targeted IgE Detection: Specifically measures mouse IgE, the immunoglobulin central to allergic reactions and type I hypersensitivity.
Ultra-Low Sample Volume: Requires only 2 µL of sample—ideal for studies with limited material or small animal models.
Versatile Sample Compatibility: Verified for serum, plasma, tissue/cell lysates, and culture supernatants, offering flexibility across experimental designs.
High Sensitivity and Specificity: Detects low levels of IgE, with negligible cross-reactivity to other immunoglobulin isotypes.
Fast Assay Completion: Full assay can be completed in one day, accelerating time-to-results.
Support Allergy and Immunology Research: Enables detailed profiling of atopic conditions, immune dysregulation, and IgE-related disease states.
Ultra-Low Sample Volume: Requires only 2 µL of sample—ideal for studies with limited material or small animal models.
Versatile Sample Compatibility: Verified for serum, plasma, tissue/cell lysates, and culture supernatants, offering flexibility across experimental designs.
High Sensitivity and Specificity: Detects low levels of IgE, with negligible cross-reactivity to other immunoglobulin isotypes.
Fast Assay Completion: Full assay can be completed in one day, accelerating time-to-results.
Support Allergy and Immunology Research: Enables detailed profiling of atopic conditions, immune dysregulation, and IgE-related disease states.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
target_organs
Respiratory Tract
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Syed H Haider et al.
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Kea Martin et al.
Journal of immunology (Baltimore, Md. : 1950), 203(11), 2791-2806 (2019-10-30)
The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 protease function in mice and MALT1 mutations in humans results in reduced regulatory T cells
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MGAMMAG-300E | 04055977291155 |
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