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Merck

RKTX1MAG-37K

MILLIPLEX® Rat Kidney Toxicity Panel

Configurable Rat Kidney Toxicity 7-Plex Panel

Synonyme(s) :

Rat renal damage panel, kidney injury biomarker panel for rats, rat drug safety kidney panel, rat nephrotoxicity multiplex assay, rat renal inflammation assay

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A propos de cet article

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Principaux documents

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species reactivity

rat

Quality Level

200

assay range

accuracy: 70-123%, standard curve range: 0.03-20 ng/mL
(IP-10, KIM-1, OPN), standard curve range: 0.03-20 ng/mL
(VEGF), standard curve range: 0.27-200 ng/mL
(TIMP-1), standard curve range: 2.06-1500 ng/mL
(Clusterin), standard curve range: 4.12-3000 ng/mL
(GSTα), inter-assay cv: <10%
intra-assay cv: <15%
(All other analytes), inter-assay cv: <20%
intra-assay cv: <30%
(GSTα)

technique(s)

multiplexing: suitable

input

urine

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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Catégories apparentées

General description

KIM-1, Clusterin, and GSTα are sensitive indicators of tubular injury and cellular stress. IP-10/CXCL10 and TIMP-1 reflect renal inflammation and tissue remodeling. OPN and VEGF-A are involved in fibrosis and vascular responses. Together, these biomarkers offer a comprehensive view of kidney toxicity and repair mechanisms in rat models.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in rat urine samples.

Analytes Included: Clusterin, GSTα, IP-10/CXCL10, KIM-1, Osteopontin (OPN), TIMP-1, VEGF-A Note: GSTα is in a competitive assay format.

Assay Characteristics: Refer to the assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:
  • Multiplex detection of 7 kidney injury biomarkers in one assay
  • Magnetic bead-based format for efficient and reproducible processing
  • Compatible with urine samples
  • High sensitivity for early detection of renal damage
Benefits:
  • Conserves sample volume and reagents through multiplexing
  • Improves data quality and reproducibility with magnetic bead format
  • Enables early detection and monitoring of kidney injury

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Consulter la Bibliothèque de documents

Javad Habibi et al.
Cardiovascular diabetology, 18(1), 40-40 (2019-03-27)
Diabetic nephropathy (DN) is characterized by glomerular and tubulointerstitial injury, proteinuria and remodeling. Here we examined whether the combination of an inhibitor of neprilysin (sacubitril), a natriuretic peptide-degrading enzyme, and an angiotensin II type 1 receptor blocker (valsartan), suppresses renal
Kidney biomarkers in MCPA-induced acute kidney injury in rats: reduced clearance enhances early biomarker performance.
Wunnapuk, K; Liu, X; Gobe, GC; Endre, ZH; Peake, PW; Grice, JE; Roberts, MS; Buckley, NA
Toxicology Letters null
Iwan P Williams et al.
mAbs, 12(1), 1685349-1685349 (2019-11-27)
IgE monoclonal antibodies hold great potential for cancer therapy. Preclinical in vivo systems, particularly those in which the antibody recognizes the host species target antigen and binds to cognate Fc receptors, are often the closest approximation to human exposure and
Nadeeka S Udawatte et al.
Frontiers in pharmacology, 11, 511-511 (2020-05-12)
Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse
Klintean Wunnapuk et al.
Toxicology letters, 225(1), 192-200 (2013-12-24)
Accidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup(®), leads to nephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in terms of suitability to detect acute kidney injury and dysfunction. The

Numéro d'article de commerce international

RéférenceGTIN
RKTX1MAG-37K-0204053252799778
RKTX1MAG-37K-0604053252799808
RKTX1MAG-37K-0704053252799815
RKTX1MAG-37K-0404053252799792
RKTX1MAG-37K-0104053252799761
RKTX1MAG-37K-0304053252799785
RKTX1MAG-37K-0504053252810718

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