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112251 α₁-Acid Glycoprotein, Human Plasma

112251
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112251-1MG
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      Description
      OverviewNative α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40 - 45% carbohydrate. Present in human plasma at concentrations of 55 - 140 mg/100 ml. Clinically, α1-AG is an acute-phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α1-AG has been observed in serum or urine of patients with Hodgkin’s disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α1-AG has an affinity for vitamin B12.
      Catalogue Number112251
      Brand Family Calbiochem®
      Synonymsα₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
      References
      ReferencesAso, H., et al. 1999. Inflammation 23, 117.
      Schmid, K., et al. 1973. Biochemistry 12, 2711.
      Product Information
      CAS number66455-27-4
      FormLyophilized
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      α₁-Acid Glycoprotein, Human Plasma Certificates of Analysis

      TitleLot Number
      112251

      References

      Reference overview
      Aso, H., et al. 1999. Inflammation 23, 117.
      Schmid, K., et al. 1973. Biochemistry 12, 2711.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2011 JSW
      Synonymsα₁-AG, C-AGP, Orosomucoid, α₁M-Seromucoid
      DescriptionNative α1-acid glycoprotein from human plasma. Glycoprotein used for the study of the structure of oligosaccharide units. Consists of 40-45% carbohydrate. Present in human plasma at concentrations of 55-140 mg/100 ml. Clinically, α1-AG is an acute phase reactant that, together with haptoglobin, indicates acute inflammation. Selectively suppresses the augmentation of NK cell activity by IFN-α and IFN-γ. The α1-AG:α1-antitrypsin ratio is useful in diagnosis of liver disease. A sialic acid-deficient α1-AG has been observed in serum or urine of patients with Hodgkin's disease, psoriatic arthritis, diabetes, and chronic myeloid leukemia. Sialic acid-deficient α1-AG has an affinity for vitamin B12.
      FormLyophilized
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      CAS number66455-27-4
      Purity≥95% by SDS-PAGE
      SolubilityAqueous buffers (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for to 3 months at (-20°C).
      Toxicity Standard Handling
      ReferencesAso, H., et al. 1999. Inflammation 23, 117.
      Schmid, K., et al. 1973. Biochemistry 12, 2711.