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100068 17-AAG - CAS 75747-14-7 - Calbiochem

100068
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Key Spec Table

Empirical FormulaCAS #
C₃₁H₄₃N₃O₈75747-14-7

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100068-500UG
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      Plastic ampoule 500 μg
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      Description
      OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
      Catalogue Number100068
      Brand Family Calbiochem®
      SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
      References
      ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Product Information
      CAS number75747-14-7
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₃₁H₄₃N₃O₈
      Chemical formulaC₃₁H₄₃N₃O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHsp90
      Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      17-AAG - CAS 75747-14-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      100068

      References

      Reference overview
      Basso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2007 RFH
      SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
      DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number75747-14-7
      Chemical formulaC₃₁H₄₃N₃O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
      Clarke, P.A., et al. 2002. Oncogene 19, 4125.
      Clarke, P.A., et al. 2000. Oncogene 19, 4125.
      Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
      Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors