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505895 CGP 35348 - CAS 123690-79-9 - Calbiochem

CGP 35348 - CAS 123690-79-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: GABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348

Primary Target: GABAB
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      123690-79-9C₈H₂₀NO₄P
      Description
      Overview

      This product has been discontinued.



      A selective antagonist of post-synaptic GABAB receptors (IC50 = 34 µM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
      Catalogue Number505895
      Brand Family Calbiochem®
      SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
      References
      ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
      Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
      Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
      Product Information
      CAS number123690-79-9
      FormWhite solid
      Hill FormulaC₈H₂₀NO₄P
      Chemical formulaC₈H₂₀NO₄P
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABAB
      Primary Target IC<sub>50</sub>34 µ
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      505895 0

      Documentation

      CGP 35348 - CAS 123690-79-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Romei, C., et al., 2010. Pharmacol. Res. 61, 547.
      Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
      Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2013 JSW
      SynonymsGABAB Receptor Antagonist, CGP 35348, CGP35348, CGP-35348
      DescriptionA selective antagonist of post-synaptic GABAB receptors (IC50 = 34 mM) that can permeate the blood brain barrier. Exhibits about 10-fold lower affinity for pre-synaptic receptors. Blocks K+-evoked glycine exocytosis in mouse spinal cord and hippocampal nerve endings. Shown to antagonize the potentiating effect of L-baclofen on noradrenaline-induced stimulation of adenylate cyclase in rat cortex slices.
      FormWhite solid
      CAS number123690-79-9
      Chemical formulaC₈H₂₀NO₄P
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRomei, C., et al., 2010. Pharmacol. Res. 61, 547.
      Staubli, U., et al., 1999. J. Neurosci. 19, 4609l.
      Olpe, H.R., et al. 1990. Eur. J. Pharmacol. 187, 27.