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05-23-2401 Calcitonin, Salmon

05-23-2401
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05-23-2401-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewSynthetic, salmon calcitonin. A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption. Has ability to cross mucous membranes. Has no significant effect on inositol phosphate accumulation.
      Catalogue Number05-23-2401
      Brand Family Calbiochem®
      References
      ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
      Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
      MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
      Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
      Product Information
      CAS number47931-85-1
      FormLyophilized
      FormulationSold on the basis of peptide content.
      Hill FormulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
      Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
      Hygroscopic Hygroscopic
      Sold on the basis of peptide contentY
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Peptide ContentY
      Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEV8000000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Calcitonin, Salmon SDS

      Title

      Safety Data Sheet (SDS) 

      Calcitonin, Salmon Certificates of Analysis

      TitleLot Number
      05-23-2401

      References

      Reference overview
      Gennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
      Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
      MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
      Chambers, T.J., et al. 1985. J. Pathol. 145, 297.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-September-2008 RFH
      DescriptionSynthetic, salmon calcitonin. Calcitonin is a single-chain peptide hormone of 32 amino acid residues with a disulfide bridge between cysteines 1 and 7. It is produced in the parafollicular C cells of the thyroid gland and acts to stimulate bone formation by osteoblasts and inhibits bone resorption. Part of the effect of calcitonin appears to be mediated through increasing cAMP concentrations in osteoclasts. Has ability to cross mucus membranes. Has no significant effect on inositol phosphate accumulation.
      FormLyophilized
      FormulationSold on the basis of peptide content.
      CAS number47931-85-1
      RTECSEV8000000
      Chemical formulaC₁₄₅H₂₄₀N₄₄O₄₈S₂
      Peptide SequenceH-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)
      Purity≥98% by HPLC
      Solubility5% Acetic acid (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 1643
      ReferencesGennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract. 48, 196.
      Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
      MacIntyre, I. et al. 1988. Clin. Orthop. 217, 45.
      Chambers, T.J., et al. 1985. J. Pathol. 145, 297.