05-647
Anti-Tyrosinase Antibody, clone T311
clone T311, Upstate®, from mouse
Synonym(s):
Anti-Anti-ATN, Anti-Anti-CMM8, Anti-Anti-OCA1, Anti-Anti-OCA1A, Anti-Anti-OCAIA, Anti-Anti-SHEP3
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
T311, monoclonal
Application:
IHC, WB
Species reactivity:
human
Citations:
12
Technique(s):
immunohistochemistry: suitable, western blot: suitable
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
T311, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG2a
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Analysis Note
routinely evaluated by immunoblot on RIPA lysates from SK-MEL-19 cells
Application
Not recommended for Immunoprecipitation
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurofilament & Neuron Metabolism
Neuronal & Glial Markers
Neurofilament & Neuron Metabolism
Neuronal & Glial Markers
This Anti-Tyrosinase Antibody, clone T311 is validated for use in WB, IH for the detection of Tyrosinase.
Biochem/physiol Actions
Tyrosinase
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
70-80kDa
Immunogen
Purified recombinant Tyrosinase corresponding to residues 5-456 of human Tyrosinase
Physical form
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Chromatography
Preparation Note
2 years at -20°C
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 1
Certificates of Analysis (COA)
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Hee-Sun Lim et al.
Chonnam medical journal, 52(1), 45-52 (2016-02-13)
As a key regulator of melanogenesis, p53 controls microphthalmia-associated transcription factor (MITF) and tyrosinase expression. The anti-oxidant enzyme heme oxygenase-1 (HO-1) is induced by various forms of cellular stress and diverse oxidative stimuli. However, few studies have examined the role
Structure-toxicity relationship of phenolic analogs as anti-melanoma agents: an enzyme directed prodrug approach.
Vad NM, Kandala PK, Srivastava SK, Moridani MY
Chemico-Biological Interactions null
Shashi K Kudugunti et al.
Chemico-biological interactions, 188(1), 1-14 (2010-08-06)
In the current work, we investigated the in vitro biochemical mechanism of Caffeic Acid Phenylethyl Ester (CAPE) toxicity and eight hydroxycinnamic/caffeic acid derivatives in vitro, using tyrosinase enzyme as a molecular target in human SK-MEL-28 melanoma cells. Enzymatic reaction models
Nikhil M Vad et al.
International journal of oncology, 35(1), 193-204 (2009-06-11)
Previously, we reported that acetaminophen (APAP) showed selective toxicity towards melanoma cell lines. In the current study, we investigated further the role of tyrosinase in APAP toxicity in SK-MEL-28 melanoma cells in the presence of a short hairpin RNA (shRNA)
Christina Michailidou et al.
Disease models & mechanisms, 2(7-8), 399-411 (2009-05-28)
Deregulated Ras signalling is implicated in most human neoplasia, exemplified by melanoma. Whereas Raf activation occurs almost ubiquitously in benign and malignant melanocytic neoplasms, implying an involvement in tumour initiation, phosphoinositide 3-kinase (PI3K) activation occurs predominantly in malignant neoplasms, implying
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 05-647 | 04053252275142 |
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