20-107
Peroxynitrite
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About This Item
UNSPSC Code:
41116012
NACRES:
NA.41
eCl@ss:
32160405
Form:
liquid
form
liquid
Quality Level
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
shipped in
dry ice
General description
Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.
Application
Peroxynitrite has been used to induce pericyte contraction in mouse brains. It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.
Biochem/physiol Actions
Peroxynitrite (ONOO−) exhibits bactericidal activity. It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.
Physical form
0.3M NaOH
Analysis Note
Routinely evaluated by treating non-stimulated A431 cells.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
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Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Beckman, J S and Crow, J P
Biochemical Society Transactions, 21, 330-334 (1993)
L Zhu et al.
Archives of biochemistry and biophysics, 298(2), 452-457 (1992-11-01)
Peroxynitrite is a strong oxidant formed by macrophages and potentially by other cells that produce nitric oxide and superoxide. Peroxynitrite was highly bactericidal, killing Escherichia coli in direct proportion to its concentration with an LD50 of 250 microM at 37
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 20-107 | 04053252671265 |