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344273-M

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride

Name: Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-&#947;-butyryl]-, Dihydrochloride
Brand: MM

≥92% (HPLC), solid, adenylate cyclase activator, Calbiochem^®

Synonym(s):

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, L-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₄₈N₂O₇ · 2HCl

CAS Number:

115116-37-5

Molecular Weight:

609.62

MDL number:

MFCD28898890

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥92% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, Chemically-modified forskolin with greater stability and water solubility than the parent compound.

Quality Segment

200

assay

≥92% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 12 mg/mL, methanol: soluble

storage temp.

10-30°C

SMILES string

Cl.Cl.N4(CCN(CC4)C)CCCC(=O)O[C@@H]1[C@]2(O[C@@](CC(=O)[C@@]2([C@@]3([C@@H]([C@@H]1O)C(CC[C@@H]3O)(C)C)C)O)(C)C=C)C

InChI key

OAJWVIUBCCGPBN-BAPSXVLWSA-N

Description

General description

A chemically modified forskolin with greater stability and water solubility. Activates adenylate cyclase (EC₅₀ = 13 µM).

Chemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC₅₀ = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.

Biochem/physiol Actions

EC50 = 13 µM in activating adenylate cyclase

Primary Target
Adenylate cyclase

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Other Notes

Yang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol.41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol.23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol.32, 133.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c