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Merck

676501

VEGFR Tyrosine Kinase Inhibitor V - Calbiochem

The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

VEGFR Tyrosine Kinase Inhibitor V - Calbiochem, N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI

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About This Item

Empirical Formula (Hill Notation):
C25H22N2O4 · xHCl · yH2O
Molecular Weight:
414.45 (anhydrous free base basis)
UNSPSC Code:
12352200

Key Documents

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assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

beige

solubility

ethanol: 0.2 mg/mL, DMSO: 0.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.

Other Notes

Harmange, J.C., et al. 2008. J. Med. Chem.51, 1649.
Weiss, M.M., et al. 2008. J. Med. Chem.51, 1668.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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