A8097
Acridine Orange hydrochloride solution
>95.0% purity (HPLC), solution
Synonym(s):
3,6-Bis(dimethylamino)acridine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C17H19N3 · HCl
CAS Number:
Molecular Weight:
301.81
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
MDL number:
Beilstein/REAXYS Number:
3575587
Product Name
Acridine Orange hydrochloride solution, 10 mg/mL in H2O, ≥95.0% (HPLC)
Quality Segment
assay
≥95.0% (HPLC)
form
solution
concentration
10 mg/mL in H2O
technique(s)
microbe id | staining: suitable
color
orange to red
εmax
47-54 at 486-492 nm in water
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
Cl[H].CN(C)c1ccc2cc3ccc(cc3nc2c1)N(C)C
InChI
1S/C17H19N3.ClH/c1-19(2)14-7-5-12-9-13-6-8-15(20(3)4)11-17(13)18-16(12)10-14;/h5-11H,1-4H3;1H
InChI key
VSTHNGLPHBTRMB-UHFFFAOYSA-N
Application
Acridine Orange hydrochloride solution has been used to study autophagic cell death. It has also been used for the staining of chromosomes.
Biochem/physiol Actions
Acridine Orange is a metachromatic dye which can stain DNA, RNA and acid glycosaminoglycans. At low concentration it intercalates into DNA and precipitates RNA. However, at high concentration it denatures and precipitates both RNA and DNA. Acridine Orange is also used to analyze autophagy. It goes into acidic organelles in a pH-dependent manner. At neutral pH, acridine orange gives a green fluorescence and in acidic conditions, it accumulates in the acidic organelle giving a bright red fluorescence.
signalword
Warning
hcodes
Hazard Classifications
Muta. 2
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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