PHR1573

Phenformin Hydrochloride

Name: Phenformin Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Phenformin hydrochloride, N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride, Phenethylbiguanide

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All Photos(1)

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₅ · HCl

CAS Number:

834-28-6

Molecular Weight:

241.72

NACRES:

NA.24

PubChem Substance ID:

329823481

UNSPSC Code:

41116107

EC Number:

212-637-3

MDL number:

MFCD00035039

Product Name

Phenformin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

YSUCWSWKRIOILX-UHFFFAOYSA-N

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H

SMILES string

Cl.NC(=N)NC(=N)NCCc1ccccc1

grade

certified reference material
pharmaceutical secondary standard

API family

phenformin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Related Categories

Analytical Reference Materials for Pharma QC

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

Reference Materials

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Phenformin Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using surface enhanced Raman spectroscopy technique and spectrophotometric technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Phenformin Hydrochloride is the hydrochloride salt of phenformin, which belongs to the second chemical class of oral hypoglycemic agents such as biguanides.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB7788 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Principles of Endocrine Pharmacology, 59(1), 18-18 (2012)

Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering

Zhang Y, et al.

Analytical Sciences, 29(10), 985-990 (2013)

Direct spectrophotometric analysis of glipizide and phenformin hydrochloride in pharmaceutical dosage forms

Phalke.NP, et al.

Indian Journal of Pharmaceutical Sciences, 59(1), 18-18 (1997)

The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer.

Seon-Hyeong Lee et al.

Cancers, 12(6) (2020-06-03)

Lung adenocarcinoma cells express high levels of ALDH1L1, an enzyme of the one-carbon pathway that catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate and NAD(P)H. In this study, we evaluated the potential of ALDH1L1 as a therapeutic target by deleting the

Comparison of CRISPR Genomic Tagging for Affinity Purification and Endogenous Immunoprecipitation Coupled with Quantitative Mass Spectrometry To Identify the Dynamic AMPKα2 Interactome.

Benjamin D Stein et al.

Journal of proteome research, 18(10), 3703-3714 (2019-08-10)

Recent advances in genome editing technologies have enabled the insertion of epitope tags at endogenous loci with relative efficiency. We describe an approach for investigation of protein interaction dynamics of the AMP-activated kinase complex AMPK using a catalytic subunit AMPKα2

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